Evidence map›Paper›PMID 27412320›Full record

SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer: a Systematic Review and Meta-analysis.

Nicola Veronese, Matteo Fassan, Laura D Wood, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Alessia Nottegar, Giuseppe Sergi, Enzo Manzato and 9 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Review
  9. A standardized pathology report for gastric cancer: 2nd edition.Journal of pathology and translational medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nicola VeroneseDepartment of Medicine, DIMED, University of Padua, Padua, Italy.
Matteo FassanDepartment of Medicine, DIMED, University of Padua, Padua, Italy.
Laura D WoodDepartment of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
Brendon StubbsHealth Service and Population Research Department, King's College London, De Crespigny Park, London, UK.
Marco SolmiDepartment of Neuroscience, University of Padua, Padua, Italy.
Paola CapelliDepartment of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Antonio PeaDepartment of Surgery, University and Hospital trust of Verona, Verona, Italy.
Alessia NottegarDepartment of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Giuseppe SergiDepartment of Medicine, DIMED, University of Padua, Padua, Italy.
Enzo ManzatoDepartment of Medicine, DIMED, University of Padua, Padua, Italy.
Sara CarraroDepartment of Medicine, DIMED, University of Padua, Padua, Italy.
Marco MaruzzoMedical Oncology Unit, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
Ivana CataldoDepartment of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Fabio BaganteDepartment of Surgery, University and Hospital trust of Verona, Verona, Italy.
Mattia BarbareschiDepartment of Pathology, Santa Chiara Hospital, Trento, Italy.
Liang ChengDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Maria BencivengaDivision of General and Upper GI Surgery, Department of Surgery, University and Hospital trust of Verona, Verona, Italy.
Giovanni de ManzoniDivision of General and Upper GI Surgery, Department of Surgery, University and Hospital trust of Verona, Verona, Italy.
Claudio LuchiniDepartment of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy. claudio.luchini@katamail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. MATERIAL AND

methodsTwo independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients' prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE-). The data were summarized using risk ratios (RRs) for the number of deaths/recurrences and hazard ratios (HRs) with 95 % confidence intervals (CI), adjusted for potential confounders.

resultsNine studies followed up 3250 patients with gastric cancer (1064 ENE+ and 2186 ENE-). ENE+ was associated with a significantly higher risk of all-cause mortality (RR = 1.70; 95 % CI: 1.43-2.03, I (2) = 66 %; HR = 2.14; 95 % CI: 1.66-2.75, I (2) = 0 %), cancer-specific mortality (RR = 1.59; 95 % CI: 1.42-1.79; HR = 1.52; 95 % CI: 1.19-1.96), and disease recurrence (RR = 3.43, 95 % CI: 1.80-6.54, I (2) = 0 %). DISCUSSION: Judging from our results, ENE in gastric cancer patients should be considered for prognostic purposes from the gross sample to the pathology report.

Indexed as

Lymphatic MetastasisHumansLymph NodesNeoplasm Recurrence, LocalOdds RatioPrognosisProportional Hazards ModelsRecurrenceStomach NeoplasmsENEExtranodal extensionGastric cancerLymph node metastasis

Identifiers

PMID27412320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.