ArticleProceedings. Biological sciences2016
Neofunctionalization of embryonic head patterning genes facilitates the positioning of novel traits on the dorsal head of adult beetles.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Shared regulatory networks link vein positioning and eyespot ring formation in butterflies.Communications biology · 2025Article
- Divergent Hox cluster collinearity in horned beetles reveals adult head patterning function of labial.Developmental biology · 2025Article
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- On the specificity of gene regulatory networks: How does network co-option affect subsequent evolution?Current topics in developmental biology · 2020Review
- The Phylogenetic Relationships ofInsects · 2019Article
- The origins of novelty from within the confines of homology: the developmental evolution of the digging tibia of dung beetles.Proceedings. Biological sciences · 2019Article
- Rhinoceros beetle horn development reveals deep parallels with dung beetles.PLoS genetics · 2018Article
- Development of functional ectopic compound eyes in scarabaeid beetles by knockdown ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Asymmetric interactions between doublesex and tissue- and sex-specific target genes mediate sexual dimorphism in beetles.Nature communications · 2017Article
- Neofunctionalization of embryonic head patterning genes facilitates the positioning of novel traits on the dorsal head of adult beetles.Proceedings. Biological sciences · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The origin and integration of novel traits are fundamental processes during the developmental evolution of complex organisms. Yet how novel traits integrate into pre-existing contexts remains poorly understood. Beetle horns represent a spectacular evolutionary novelty integrated within the context of the adult dorsal head, a highly conserved trait complex present since the origin of insects. We investigated whether otd1/2 and six3, members of a highly conserved gene network that instructs the formation of the anterior end of most bilaterians, also play roles in patterning more recently evolved traits. Using ablation-based fate-mapping, comparative larval RNA interference (RNAi) and transcript sequencing, we found that otd1/2, but not six3, play a fundamental role in the post-embryonic formation of the adult dorsal head and head horns of Onthophagus beetles. By contrast, neither gene appears to pattern the adult head of Tribolium flour beetles even though all are expressed in the dorsal head epidermis of both Onthophagus and Tribolium We propose that, at least in beetles, the roles of otd genes during post-embryonic development are decoupled from their embryonic functions, and that potentially non-functional post-embryonic expression in the dorsal head facilitated their co-option into a novel horn-patterning network during Onthophagus evolution.
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