Evidence map›Paper›PMID 27412206›Full record

ReviewCanadian family physician Medecin de famille canadien2016

Approach to lymphogranuloma venereum.

Patrick O'Byrne, Paul MacPherson, Stephane DeLaplante, Gila Metz, Andree Bourgault

Abstract readCase ReportsReview
In one paragraph

Review in Canadian family physician Medecin de famille canadien, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  2. Article
  3. Intestinal giardiasis and spirochetosis causing unintentional weight loss in a 40-year-old man.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  4. Article
  5. Article
  6. Genital ulcer disease: A review.Journal of family medicine and primary care · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Patrick O'ByrneAssociate Professor of Nursing at the University of Ottawa in Ontario. pjobyrne@uottawa.ca.
Paul MacPhersonAssociate Professor of Medicine at the University of Ottawa.
Stephane DeLaplanteFamily physician and Lecturer of Medicine at the University of Ottawa.
Gila MetzMedical Director of the Ottawa Public Health Sexual Health Centre.
Andree BourgaultNurse practitioner at the Ottawa Public Health Sexual Health Centre.
University of Ottawa · CASexual Health Clinic · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review the literature about lymphogranuloma venereum (LGV) and to provide an overview and discussion of practice guidelines. SOURCES OF INFORMATION: The terms Chlamydia trachomatis and lymphogranuloma venereum were searched separately in PubMed. Empirical studies, practice reviews, and clinical guidelines were included. All reference lists were reviewed for additional articles. MAIN MESSAGE: Since 2003, there has been a resurgence of LGV among men who have sex with men in many Western countries, including Canada. Although LGV is a serovar of Chlamydia trachomatis (serovar L), it can invade regional lymph nodes, and consequently presents with different symptoms than the other subtypes of chlamydia (serovars A through K). Specifically, LGV transitions through 3 phases: a painless papule or ulcer at the site of inoculation; invasion of the regional lymph nodes, which can present with an inguinal or rectal syndrome; and irreversible destruction of lymph tissue. In contrast, chlamydia serovars A to K exclusively produce superficial mucosal infections. Lymphogranuloma venereum also requires a different treatment regimen than other chlamydia serovars.

conclusionIn light of the current resurgence of LGV, its unique symptoms and clinical course, and its requirement for a different treatment than other chlamydia serovars, it is important for primary care providers to recognize when LGV should be included as an appropriate differential diagnosis.

Indexed as

Chlamydia trachomatisAdultAnti-Bacterial AgentsDoxycyclineHumansLymphogranuloma VenereumMalePractice Guidelines as TopicAnti-Bacterial AgentsDoxycycline

Identifiers

PMID27412206
PMCPMC4955081
OpenAlexW2484899643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.