Evidence map›Paper›PMID 27412106›Full record

SynthesisBMJ open2016

Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses.

Sergio Rueda, Sanjana Mitra, Shiyi Chen, David Gogolishvili, Jason Globerman, Lori Chambers, Mike Wilson, Carmen H Logie, Qiyun Shi, Sara Morassaei and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 506 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
506citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

506 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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446 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sergio RuedaInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Institute for Work and Health, Toronto, Ontario, Canada.ORCID 0000-0002-0654-6421
Sanjana MitraThe Ontario HIV Treatment Network, Toronto, Ontario, Canada.
Shiyi ChenThe Ontario HIV Treatment Network, Toronto, Ontario, Canada.
David GogolishviliThe Ontario HIV Treatment Network, Toronto, Ontario, Canada.
Jason GlobermanThe Ontario HIV Treatment Network, Toronto, Ontario, Canada.
Lori ChambersSchool of Social Work, McMaster University, Hamilton, Ontario, Canada.
Mike WilsonDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada McMaster Health Forum, McMaster University, Hamilton, Ontario, Canada.
Carmen H LogieFactor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.
Qiyun ShiThe Ontario HIV Treatment Network, Toronto, Ontario, Canada.
Sara MorassaeiInstitute for Work and Health, Toronto, Ontario, Canada.
Sean B RourkeDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada The Ontario HIV Treatment Network, Toronto, Ontario, Canada Centre for Research on Inner City Health, Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Funding

CIHR
6 · The paper itself

Abstract

objectiveTo conduct a systematic review and series of meta-analyses on the association between HIV-related stigma and health among people living with HIV. DATA SOURCES: A structured search was conducted on 6 electronic databases for journal articles reporting associations between HIV-related stigma and health-related outcomes published between 1996 and 2013. STUDY ELIGIBILITY CRITERIA: Controlled studies, cohort studies, case-control studies and cross-sectional studies in people living with HIV were considered for inclusion. OUTCOME MEASURES: Mental health (depressive symptoms, emotional and mental distress, anxiety), quality of life, physical health, social support, adherence to antiretroviral therapy, access to and usage of health/social services and risk behaviours.

results64 studies were included in our meta-analyses. We found significant associations between HIV-related stigma and higher rates of depression, lower social support and lower levels of adherence to antiretroviral medications and access to and usage of health and social services. Weaker relationships were observed between HIV-related stigma and anxiety, quality of life, physical health, emotional and mental distress and sexual risk practices. While risk of bias assessments revealed overall good quality related to how HIV stigma and health outcomes were measured on the included studies, high risk of bias among individual studies was observed in terms of appropriate control for potential confounders. Additional research should focus on elucidating the mechanisms behind the negative relationship between stigma and health to better inform interventions to reduce the impact of stigma on the health and well-being of people with HIV.

conclusionsThis systematic review and series of meta-analyses support the notion that HIV-related stigma has a detrimental impact on a variety of health-related outcomes in people with HIV. This review can inform the development of multifaceted, intersectoral interventions to reduce the impact of HIV-related stigma on the health and well-being of people living with HIV.

Indexed as

Health Services AccessibilityHIV InfectionsMedication AdherenceSocial StigmaSocial SupportDepressionHealth ServicesHealth StatusHumansQuality of LifeRisk-TakingSexual BehaviorSOCIAL MEDICINE

Identifiers

PMID27412106
PMCPMC4947735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.