Observational studyBMJ open2016
Impact of coronary collaterals on in-hospital and 5-year mortality after ST-elevation myocardial infarction in the contemporary percutaneous coronary intervention era: a prospective observational study.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Coronary collateral circulation and mortality in ST-elevation myocardial infarction undergoing primary PCI: an updated systematic review and meta-analysis of 18,443 patients.BMC cardiovascular disorders · 2026Pooled it
- Prognostic implications of the rapid recruitment of coronary collaterals during ST elevation myocardial infarction (STEMI): a meta-analysis of over 14,000 patients.Journal of thrombosis and thrombolysis · 2021Pooled it
- A Perturb-seq screen guided by species divergence uncovers pathways for collateral artery formation.bioRxiv : the preprint server for biology · 2026Article
- Association between the pan-immune-inflammation value and coronary collateral circulation in chronic total coronary occlusive patients.BMC cardiovascular disorders · 2024Article
- Machine-learning based risk prediction of in-hospital outcomes following STEMI: the STEMI-ML score.Frontiers in cardiovascular medicine · 2024Article
- The predictive value of the triglyceride-glucose index for cardiovascular events in patients with coronary chronic total occlusion.Cardiovascular diabetology · 2022Article
- With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Manual Thrombus Aspiration and its Procedural Stroke Risk in Myocardial Infarction.Journal of the American Heart Association · 2021Article
- Association between the triglyceride glucose index and coronary collateralization in coronary artery disease patients with chronic total occlusion lesions.Lipids in health and disease · 2021Observational
- Prevalence of the Japanese high bleeding risk criteria and its prognostic significance for fatal bleeding in patients with acute myocardial infarction.Heart and vessels · 2021Article
- Impact of age on reperfusion success and long-term prognosis in ST-segment elevation myocardial infarction - A cardiac magnetic resonance imaging study.International journal of cardiology. Heart & vasculature · 2021Article
- Article
- Does the extent of collaterals influence the severity of the myocardial injury as assessed by elevation in biomarkers?Journal of cardiovascular and thoracic research · 2021Article
- Incomplete protective effect of coronary collateral circulation for acute myocardial infarction patients.Medicine · 2020Article
- Comparison between radial versus femoral percutaneous coronary intervention access in Indonesian hospitals, 2017-2018: A prospective observational study of a national registry.International journal of cardiology. Heart & vasculature · 2020Article
- Spontaneous coronary collateral recruitment in patients with recurrent ST elevation myocardial infarction (STEMI).Heart and vessels · 2020Article
- Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody.Journal of the American Heart Association · 2019Article
- Impact of Admission Blood Glucose on Coronary Collateral Flow in Patients with ST-Elevation Myocardial Infarction.Cardiology research and practice · 2018Article
- Do collaterals to infarct bed in STE-ACS patients undergoing emergent percutaneous coronary revascularization matter? An assessment of a prospective pool for in-hospital course.Indian heart journalArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the short-term and long-term prognostic impacts of acute phase coronary collaterals to occluded infarct-related arteries (IRA) after ST-elevation myocardial infarction (STEMI) in the percutaneous coronary intervention (PCI) era.
designA prospective observational study.
settingOsaka Acute Coronary Insufficiency Study (OACIS) in Japan.
participants3340 patients with STEMI from the OACIS database who were admitted to hospitals within 24 hours from the onset and who had a completely occluded IRA.
interventionsPatients were divided into 4 groups according to the Rentrop collateral score (RCS) by angiography on admission (RCS-0, no visible collaterals; RCS-1, collaterals without IRA filling; RCS-2, collaterals with partial IRA filling; and RCS-3, collaterals with complete IRA filling). PRIMARY OUTCOME MEASURES: In-hospital and 5-year mortality.
resultsPatients with RCS-0/3 were older than patients with RCS-1/2, and the prevalence of previous myocardial infarction was highest in patients with RCS-3. Median peak creatinine phosphokinase levels decreased as RCS increases (p<0.001), suggesting the acute cardioprotective effects of collaterals. Although RCS-1 and RCS-2 collaterals were associated with better in-hospital mortality (adjusted OR 0.48, p=0.046 and 0.38, p=0.010 for RCS-1 and RCS-2, respectively) and 5-year mortality (adjusted HR 0.53, p=0.004 and 0.46, p<0.001 for RCS-1 and RCS-2, respectively) as compared with R-0, presence of RCS-3 collaterals was not associated with improved in-hospital (adjusted OR 1.35, p=0.331) and 5-year mortality (adjusted HR 0.98, p=0.920), possibly because worse clinical profiles in patients with RCS-3 may mask mortality benefit of coronary collaterals.
conclusionsPresence of acute phase coronary collaterals such as RCS-1 and RCS-2 were associated with better in-hospital and 5-year mortality after STEMI in the contemporary PCI era.
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