Evidence map›Paper›PMID 27412076›Full record

ArticleArchivum immunologiae et therapiae experimentalis2017

Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells.

Geoffrey Brown, Aleksandra Marchwicka, Alan Cunningham, Kai-Michael Toellner, Ewa Marcinkowska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archivum immunologiae et therapiae experimentalis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Deregulation of All-International journal of molecular sciences · 2023
    Review
  11. Review
  12. Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Antagonizing RARγ Drives Necroptosis of Cancer Stem Cells.International journal of molecular sciences · 2022
    Review
  15. Lessons to cancer from studies of leukemia and hematopoiesis.Frontiers in cell and developmental biology · 2022
    Review
  16. Article
  17. Review
  18. A Network Pharmacology-Based Study on the Anti-Lung Cancer Effect of Dipsaci Radix.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Geoffrey BrownInstitute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. g.brown@bham.ac.uk.
Aleksandra MarchwickaLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Alan CunninghamInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Kai-Michael ToellnerInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Ewa MarcinkowskaLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
University of Birmingham · GBUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activities of the retinoic acid receptor (RAR)α and RARγ are important to hematopoiesis. Here, we have investigated the effects of receptor selective agonists and antagonists on the primitive human hematopoietic cell lines KG1 and NB-4 and purified normal human hematopoietic stem cells (HSCs). Agonizing RARα (by AGN195183) was effective in driving neutrophil differentiation of NB-4 cells and this agonist synergized with a low amount (10 nM) of 1α,25-dihydroxyvitamin D

Indexed as

AnimalsAntigens, CD34Cell DifferentiationCell LineCell Line, TumorCell ProliferationCells, CulturedHaplorhiniHematopoiesisHematopoietic Stem CellsHL-60 CellsHumansMyeloid CellsNeutrophilsProtein BindingReceptors, Retinoic AcidAGN 195183Antigens, CD34Receptors, Retinoic AcidRetinoic Acid Receptor alphaRetinoic Acid Receptor gammaRetinoidsTretinoinAgonistAll-trans retinoic acidAntagonistHematopoiesisMonocytesNeutrophilsRetinoic acid receptor

Identifiers

PMID27412076
PMCPMC5274652
OpenAlexW2471059986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.