Evidence map›Paper›PMID 27411951›Full record

ArticleScientific reports2016

N-terminal pro b-type natriuretic peptide (NT-pro-BNP) -based score can predict in-hospital mortality in patients with heart failure.

Ya-Ting Huang, Yuan-Teng Tseng, Tung-Wei Chu, John Chen, Min-Yu Lai, Woung-Ru Tang, Chih-Chung Shiao

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Prognostic Models in Heart Failure: Hope or Hype?Journal of personalized medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ya-Ting HuangDoctoral Candidate, Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University. No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan, R.O.C.
Yuan-Teng TsengDivision of Cardiovascular Medicine, Department of Internal Medicine, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
Tung-Wei ChuDivision of Cardiovascular Surgery, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
John ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
Min-Yu LaiDepartment of Nursing, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
Woung-Ru TangGraduate Institute of Nursing, Chang Gung University, Taiwan 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan, ROC.
Chih-Chung ShiaoDivision of Nephrology in Department of Internal Medicine, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
Saint Mary's Hospital Luodong · TWChang Gung University · TWChang Gung University of Science and Technology · TWUniversity of Saint Mary · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum N-terminal pro b-type natriuretic peptide (NT-pro-BNP) testing is recommended in the patients with heart failure (HF). We hypothesized that NT-pro-BNP, in combination with other clinical factors in terms of a novel NT-pro BNP-based score, may provide even better predictive power for in-hospital mortality among patients with HF. A retrospective study enrolled adult patients with hospitalization-requiring HF who fulfilled the predefined criteria during the period from January 2011 to December 2013. We proposed a novel scoring system consisting of several independent predictors including NT-pro-BNP for predicting in-hospital mortality, and then compared the prognosis-predictive power of the novel NT-pro BNP-based score with other prognosis-predictive scores. A total of 269 patients were enrolled in the current study. Factors such as "serum NT-pro-BNP level above 8100 mg/dl," "age above 79 years," "without taking angiotensin converting enzyme inhibitors/angiotensin receptor blocker," "without taking beta-blocker," "without taking loop diuretics," "with mechanical ventilator support," "with non-invasive ventilator support," "with vasopressors use," and "experience of cardio-pulmonary resuscitation" were found as independent predictors. A novel NT-pro BNP-based score composed of these risk factors was proposed with excellent predictability for in-hospital mortality. The proposed novel NT-pro BNP-based score was extremely effective in predicting in-hospital mortality in HF patients.

Indexed as

AdultAgedAged, 80 and overBiomarkersFemaleHeart FailureHospital MortalityHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsRetrospective StudiesRisk FactorsSensitivity and SpecificityBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID27411951
PMCPMC4944149
OpenAlexW4255956480

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.