ReviewNature reviews. Rheumatology2016
Insight into rheumatological cause and effect through the use of Mendelian randomization.
Review in Nature reviews. Rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Major depressive disorder and the risk of irritable bowel syndrome: A Mendelian randomization study.Molecular genetics & genomic medicine · 2024Pooled it
- Pooled it
- Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review.International journal of epidemiology · 2023Pooled it
- Pooled it
- Pooled it
- Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation.Scientific reports · 2022Trial
- [Psoriatic arthritis as MHC-I-associated disease].Zeitschrift fur Rheumatologie · 2026Review
- Exploring the effects of occupational noise on cardiovascular and cerebrovascular diseases: A Mendelian randomization study.Medicine · 2026Article
- SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis.BMC rheumatology · 2025Article
- Mendelian Randomization Studies: A Metric for Quality Evaluation.Gout, urate, and crystal deposition disease · 2025Article
- Exploring blood immune cells in the protective effects of gut microbiota on rheumatic heart disease based on Mendelian randomization analysis.Scientific reports · 2025Article
- Association between BMD and coronary artery calcification: an observational and Mendelian randomization study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Observational
- Association of Smoking with Chronic Kidney Disease Stages 3 to 5: A Mendelian Randomization Study.Health data science · 2024Article
- Association between knee osteoarthritis and mortality: a serial propensity score-matched cohort study.The Korean journal of internal medicine · 2023Article
- The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout.Frontiers in nutrition · 2022Review
- Genetic correlations between traits associated with hyperuricemia, gout, and comorbidities.European journal of human genetics : EJHG · 2021Article
- Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations.Human genetics · 2021Article
- Longitudinal development of incident gout from low-normal baseline serum urate concentrations: individual participant data analysis.BMC rheumatology · 2021Article
- Overlapping-sample Mendelian randomisation with multiple exposures: a Bayesian approach.BMC medical research methodology · 2020Article
- A Bayesian approach to Mendelian randomization with multiple pleiotropic variants.Biostatistics (Oxford, England) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Establishing causality of risk factors is important to determine the pathogenetic mechanisms underlying rheumatic diseases, and can facilitate the design of interventions to improve care for affected patients. The presence of unmeasured confounders, as well as reverse causation, is a challenge to the assignment of causality in observational studies. Alleles for genetic variants are randomly inherited at meiosis. Mendelian randomization analysis uses these genetic variants to test whether a particular risk factor is causal for a disease outcome. In this Review of the Mendelian randomization technique, we discuss published results and potential applications in rheumatology, as well as the general clinical utility and limitations of the approach.
Indexed as
Identifiers
27411906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.