Evidence map›Paper›PMID 27411806›Full record

ArticleJournal of neurology2016

MRI gray and white matter measures in progressive supranuclear palsy and corticobasal syndrome.

Neeraj Upadhyay, Antonio Suppa, Maria Cristina Piattella, Matteo Bologna, Flavio Di Stasio, Alessandra Formica, Francesca Tona, Carlo Colosimo, Alfredo Berardelli, Patrizia Pantano

Abstract read
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In one paragraph

Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Journal of neurology · 2020
    Article
  11. Article
  12. Article
  13. Corticobasal degeneration and corticobasal syndrome: A review.Clinical parkinsonism & related disorders · 2019
    Review
  14. Disease-related patterns of in vivo pathology in Corticobasal syndrome.European journal of nuclear medicine and molecular imaging · 2018
    Article
  15. Neuropsychiatric disturbances in atypical parkinsonian disorders.Neuropsychiatric disease and treatment · 2018
    Review
  16. Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?Movement disorders : official journal of the Movement Disorder Society · 2017
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Neeraj UpadhyayDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Antonio SuppaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Maria Cristina PiattellaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Matteo BolognaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Flavio Di StasioIRCCS INM Neuromed, Pozzilli, IS, Italy.
Alessandra FormicaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Francesca TonaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Carlo ColosimoDepartment of Neurology, Santa Maria University Hospital, Terni, Italy.
Alfredo BerardelliDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Patrizia PantanoDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy. patrizia.pantano@uniroma1.it.
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITSanta Maria Nuova Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated MRI measures of gray and white matter damages in 19 patients with progressive supranuclear palsy (PSP), 11 with corticobasal syndrome (CBS), and 14 healthy subjects (HS) to differentiate patients with PSP from those with CBS. We calculated surface-based maps of the cortical volume, cortical thickness, surface area, and voxel level maps of sub-cortical volume, and diffusion tensor imaging parameters using automated scripts implemented in FreeSurfer and FSL toolboxes. No significant differences in cortical volume loss were observed between PSP and CBS. When cortical volume was divided into cortical thickness and surface area, cortical thickness in peri-rolandic brain regions was significantly smaller in CBS than in PSP patients, whereas surface area was significantly smaller in PSP than HS. We also found widespread volume loss in sub-cortical structures in patients with PSP and CBS in comparison to HS. Both patient groups displayed diffusion tensor imaging abnormalities: compared to HS, widespread fractional anisotropy and radial diffusivity changes were observed in PSP, whereas axial and radial diffusivity changes were prominent in CBS. Mini-mental state examination positively correlated with diffusion changes in patients with PSP. In conclusion, cortical thickness, surface area, and diffusion tensor imaging parameters may be sensitive enough to help differentiate patients with PSP from those with CBS.

Indexed as

AgedAnalysis of VarianceAnisotropyBrainBrain DiseasesDiffusion Tensor ImagingFemaleGray MatterHumansImage Processing, Computer-AssistedMaleMiddle AgedPsychiatric Status Rating ScalesPyramidal TractsSupranuclear Palsy, ProgressiveWhite MatterCorticobasal syndromeDTI parametersProgressive supranuclear palsySurface-based morphometric measures

Identifiers

PMID27411806
OpenAlexW2471374275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.