ArticleDiabetes care2016
Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study.
Article in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2017Pooled it
- A Randomized Controlled Clinical Trial of Lifestyle Intervention and Pioglitazone for Normalization of Glucose Status in Chinese with Prediabetes.Journal of diabetes research · 2022Trial
- Association between heavy metals and risk of cardiovascular diseases in US adults with prediabetes from NHANES 2011-2018.BMC public health · 2025Article
- Impact of the triglyceride-glucose index on 28-day mortality in non-diabetic critically Ill patients with sepsis: a retrospective cohort analysis.BMC infectious diseases · 2024Article
- Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial.Experimental and therapeutic medicine · 2023Article
- Modifiable predictors of type 2 diabetes mellitus and roles of insulin resistance and β-cell function over a 6-year study and 30-year follow-up.Journal of endocrinological investigation · 2023Article
- Development of models to predict 10-30-year cardiovascular disease risk using the Da Qing IGT and diabetes study.Diabetology & metabolic syndrome · 2023Article
- Primary care providers' knowledge, attitudes, and practices related to prediabetes in China: A cross-sectional study.Frontiers in public health · 2023Article
- Phenotype of higher post-load insulin response as a predictor of all-cause mortality and cardiovascular mortality in the Chinese non-diabetic population.Diabetology & metabolic syndrome · 2022Article
- Dissonance in the discourse of the duration of diabetes: A mixed methods study of patient perceptions and clinical practice.Health expectations : an international journal of public participation in health care and health policy · 2021Article
- Article
- Years of potential life lost in pre-diabetes and diabetes mellitus: data from a 40-year follow-up of the Israel study on Glucose intolerance, Obesity and Hypertension.BMJ open diabetes research & care · 2021Article
- Body Composition and Metabolic Improvement in Patients Followed Up by a Multidisciplinary Team for Obesity in China.Journal of diabetes research · 2021Article
- Does diabetes prevention translate into reduced long-term vascular complications of diabetes?Diabetologia · 2019Review
- Survey of primary care providers' knowledge of screening for, diagnosing and managing prediabetes.Journal of general internal medicine · 2017Article
- Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013.Cardiovascular diabetology · 2016Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivePeople with impaired glucose tolerance (IGT) have increased risk of mortality and a high risk of progression to diabetes, but the extent that the excess mortality is associated with IGT per se or is the result of subsequent diabetes is unclear. RESEARCH DESIGN AND
methodsWe compared mortality before and after the development of diabetes among 542 persons with IGT initially who participated in a 6-year lifestyle diabetes prevention trial and were followed-up from 1986 to 2009.
resultsDuring the 23-year follow-up, 174 (32.1%) died, with an overall death rate of 15.9/1,000 person-years. The majority of deaths (74.7%; 130 of 174) occurred after progression to type 2 diabetes, with age-adjusted death rates of 11.1/1,000 person-years (95% CI 8.2-12.0) before and 19.4/1,000 person-years (95% CI 11.9-23.3) after the development of type 2 diabetes. The cumulative mortality was 37.8% (95% CI 33.1-42.2%) in participants who developed type 2 diabetes during first 10 years of follow-up, 28.6% (95% CI 21.6-35.0%) in those who progressed to type 2 diabetes in 10-20 years, and 13.9% (95% CI 7.0-20.3%) in those who did not develop to type 2 diabetes within 20 years. Time-dependent multivariate Cox proportional hazards analyses, with adjustment for baseline age, sex, intervention, and other potential confounding risk factors, showed that the development of type 2 diabetes was associated with a 73% higher risk of death (hazard ratio 1.73 [95% CI 1.18-2.52]).
conclusionsAs elsewhere, IGT is associated with increased risk of mortality in China, but much of this excess risk is attributable to the development of type 2 diabetes.
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