ArticleBMC complementary and alternative medicine2016
The electroacupuncture-induced analgesic effect mediated by 5-HT1, 5-HT3 receptor and muscarinic cholinergic receptors in rat model of collagenase-induced osteoarthritis.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- The Role of Serotonergic System in Parkinson's Disease-Related Pain.Neuroscience bulletin · 2026Review
- Electroacupuncture Alleviates KOA-Induced Pain and Cartilage Degeneration via NGF/TrkA Pathway.Journal of pain research · 2026Article
- Advances in Electroacupuncture for Treatment of Knee Osteoarthritis: Mechanisms, Efficacy, and Future Directions.Journal of pain research · 2025Review
- Therapeutic Potential of Acupuncture in Knee Osteoarthritis: Clinical Efficacy and Mechanistic Insights.Journal of inflammation research · 2025Review
- Article
- Effect of Traditional Chinese Non-Pharmacological Therapies on Knee Osteoarthritis: A Narrative Review of Clinical Application and Mechanism.Orthopedic research and reviews · 2024Review
- Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model.Journal of traditional and complementary medicine · 2022Article
- Is acupuncture effective for knee osteoarthritis? A protocol for a systematic review and meta-analysis.BMJ open · 2022Article
- Effective Oriental Magic for Analgesia: Acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- 5-HTFrontiers in neuroscience · 2021Article
- Role of Neuroimmune Crosstalk in Mediating the Anti-inflammatory and Analgesic Effects of Acupuncture on Inflammatory Pain.Frontiers in neuroscience · 2021Review
- Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2/CCR2 signaling pathway.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Article
- The Involvement of Descending Pain Inhibitory System in Electroacupuncture-Induced Analgesia.Frontiers in integrative neuroscience · 2019Review
- Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Tackling Osteoarthritic Knee Pain with Electroacupuncture.Chinese journal of integrative medicine · 2018Article
- Anti-osteoarthritic effects of ChondroT in a rat model of collagenase-induced osteoarthritis.BMC complementary and alternative medicine · 2018Article
- A rat model for studying electroacupuncture analgesia on acute visceral hyperalgesia.Experimental animals · 2018Article
- Acupuncture decreased the risk of coronary heart disease in patients with fibromyalgia in Taiwan: a nationwide matched cohort study.Arthritis research & therapy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) is an degenerative disease characterized by chronic joint pain. Complementary and alternative treatment such as acupuncture have been utilized to alleviate pain. The objective of this study was to investigate the analgesic mechanisms of electroacupuncture (EA) in the collagenase-induced osteoarthritis (CIOA) rat model.
methodsFour weeks after inducing CIOA by injecting collagenase solution into the left knee of 5-week-old male Sprague-Dawley rats, 2 Hz and 100 Hz EA on Zusanli (ST 36) was performed. The analgesic effect of EA was evaluated by the tail flick latency (TFL) and paw pressure threshold (PPT) tests. To investigate the analgesic mechanism, serotonergic and muscarinic cholinergic receptor agonists and antagonists were injected 20 min prior to EA and the resultant changes were evaluated by the TFL and PPT tests.
resultsEA on Zusanli (ST 36) demonstrated an analgesic effect in the CIOA rat model. The 2 Hz EA treatment showed a significantly greater analgesic effect than the 100 Hz treatment. The analgesic effect of 2 Hz EA was not strengthened by 5-HT1, 5-HT2, 5-HT3, and muscarinic cholinergic receptor agonist pretreatment, was blocked by 5-HT1, 5-HT3, and muscarinic cholinergic receptor antagonist pretreatment, but not blocked by 5-HT2 receptor antagonist pretreatment.
conclusionsIn the CIOA rat model, EA on Zusanli (ST 36) exhibited analgesic effects, and 2 Hz EA resulted in a significantly greater analgesic effect than 100 Hz EA. The analgesic effect of 2 Hz EA was reduced by pretreatment of 5-HT1 receptor, 5-HT3 receptor and muscarinic cholinergic receptor antagonists.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.