ReviewCritical care (London, England)2016
The pathophysiological basis and consequences of fever.
Review in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 5 syntheses or guidelines pooled it, 336 citations in OpenAlex.
- Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis.Critical care (London, England) · 2024Pooled it
- The protective effect of breastfeeding on febrile seizures: a systematic review with meta-analysis.European journal of pediatrics · 2024Pooled it
- The impact of pulse oximetry on diagnosis, management and outcomes of acute febrile illness in low-income and middle-income countries: a systematic review.BMJ global health · 2021Pooled it
- The efficacy of steroids in reducing morbidity and mortality from extreme hyperthermia and heatstroke-A systematic review.Pharmacology research & perspectives · 2020Pooled it
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature.Critical care (London, England) · 2021Trial
- Admission body temperature and in-hospital mortality in critically ill children with pneumonia: a retrospective cohort study.BMC pediatrics · 2026Article
- Determinants of Brain Tissue Normoxia in Patients with Large Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Evaluation of Parental Knowledge and Practices in Pediatric Fever Management Among Iranian Families: A Cross-Sectional Study.Pediatric reports · 2026Article
- Oral and plasma microbiome in the context of acute febrile illness.medRxiv : the preprint server for health sciences · 2026Article
- [Analysis of risk factors and construction of a predictive model for perioperative urosepsis].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Identification of specific molecular markers in severe heatstroke using transcriptomics techniques.International journal of legal medicine · 2026Article
- The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026Review
- Pathway thermodynamic analysis postulates change in glutamate metabolism as a key factor in modulating immune responses.Immunometabolism (Cobham, Surrey) · 2026Article
- Article
- Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever.Frontiers in physiology · 2026Article
- Hydralazine Attenuates Lipopolysaccharide-Induced Murine Myocardial Dysfunction by Inhibition of Semicarbazide-Sensitive Amine Oxidase.Antioxidants (Basel, Switzerland) · 2025Article
- Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- A brain-body perspective on thermoregulatory adaptation.Current biology : CB · 2025Review
- Aloifol I Derived fromACS pharmacology & translational science · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are numerous causes of a raised core temperature. A fever occurring in sepsis may be associated with a survival benefit. However, this is not the case for non-infective triggers. Where heat generation exceeds heat loss and the core temperature rises above that set by the hypothalamus, a combination of cellular, local, organ-specific, and systemic effects occurs and puts the individual at risk of both short-term and long-term dysfunction which, if severe or sustained, may lead to death. This narrative review is part of a series that will outline the pathophysiology of pyrogenic and non-pyrogenic fever, concentrating primarily on the pathophysiology of non-septic causes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.