Evidence map›Paper›PMID 27411319›Full record

ReviewCurrent allergy and asthma reports2016

Pros and Cons of Clinical Basophil Testing (BAT).

Hans Jürgen Hoffmann, Edward F Knol, Martha Ferrer, Lina Mayorga, Vito Sabato, Alexandra F Santos, Bernadette Eberlein, Anna Nopp, Donald MacGlashan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Flow Cytometry in Human Cells Exposed to Tick Salivary Proteins.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Basophil Stimulation and Signaling Pathways.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  15. Basophil Activation Test: Old and New Applications in Allergy.Current allergy and asthma reports · 2018
    Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hans Jürgen HoffmannDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark. hjh@clin.au.dk.
Edward F KnolDepartments of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Martha FerrerDepartment of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain.
Lina MayorgaResearch Laboratory and Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
Vito SabatoDepartment of Immunology-Allergology-Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
Alexandra F SantosDepartment of Paediatric Allergy, Division of Asthma, Allergy & Lung Biology, King's College London, London, UK.
Bernadette EberleinDepartment of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
Anna NoppImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Donald MacGlashanJohns Hopkins, Baltimore, USA.

Funding

The Role of CD32 in the Basophil Response to Specific ImmunotherapyU01AI100952 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MACGLASHAN, DONALD W · 2014 to 2018
$2.0M
Medical Research Council G0902018Medical Research Council G1000758Medical Research Council MR/M008517/1NIAID NIH HHS U01 AI100952
6 · The paper itself

Abstract

purpose of reviewWe review basophil testing by flow cytometry with an emphasis on advantages and disadvantages. RECENT

findingsThere are many tools available to assess the presence and severity of allergic diseases in patients. For 50 years, peripheral blood basophils have been used as tools to study these diseases. It is a very accessible cell that binds IgE antibody and secretes the classical mediators responsible for the symptoms of allergic reactions. In the last decade, an even more accessible methodology, using flow cytometry, has been developed to enhance the ability to use basophils for both mechanistic and clinical diagnostics. Basophil testing has been included in diagnostics for different forms of allergies as well as to monitor disease status. A variety of studies have begun to establish both precise methods and their clinical relevance for disease diagnosis, but there remain some important questions on how to take optimal advantage of the behaviours of basophils.

Indexed as

BasophilsFlow CytometryHumansHypersensitivityAllergyBasophil granulocyteBATCD63Chronic urticariaMast cell

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.