ArticleArquivos brasileiros de cardiologia2016
Effect of Fetal Hypothyroidism on Cardiac Myosin Heavy Chain Expression in Male Rats.
Article in Arquivos brasileiros de cardiologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 16 citations in OpenAlex.
- Relationship of Thyroid Volume and Function with Ankle-Brachial Index, Toe-Brachial Index, and Toe Pressure in Euthyroid People Aged 18-65.Medicina (Kaunas, Lithuania) · 2024Article
- Region-specific effects of antenatal/early postnatal hypothyroidism on endothelial NO-pathway activity in systemic circulation.Current research in physiology · 2022Article
- Changes in nitric oxide synthase levels are associated with impaired cardiac function and tolerance to ischemia-reperfusion injury in male rats with transient congenital hypothyroidism.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Role of inducible nitric oxide synthase in myocardial ischemia-reperfusion injury in sleep-deprived rats.Sleep & breathing = Schlaf & Atmung · 2018Article
- Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway.Iranian journal of basic medical sciences · 2018Article
- Effect of fetal hypothyroidism on MyomiR network and its target gene expression profiles in heart of offspring rats.Molecular and cellular biochemistry · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid hormone deficiency during fetal life could affect the cardiac function in later life. The mechanism underlying this action in fetal hypothyroidism (FH) in rats has not been elucidated thus far.
objectiveThe aim of this study is to evaluation the effect of FH on cardiac function in male rats and to determine the contribution of α-myosin heavy chain (MHC) and β-MHC isoforms.
methodsSix pregnant female rats were randomly divided into two groups: The hypothyroid group received water containing 6-propyl-2-thiouracil during gestation and the controls consumed tap water. The offspring of the rats were tested in adulthood. Hearts from the FH and control rats were isolated and perfused with langendroff setup for measuring hemodynamic parameters; also, the heart mRNA expressions of α- MHC and β-MHC were measured by qPCR.
resultsBaseline LVDP (74.0 ± 3.1 vs. 92.5 ± 3.2 mmHg, p < 0.05) and heart rate (217 ± 11 vs. 273 ± 6 beat/min, p < 0.05) were lower in the FH rats than controls. Also, these results showed the same significance in ±dp/dt. In the FH rats, β-MHC expression was higher (201%) and α- MHC expression was lower (47%) than control.
conclusionThyroid hormone deficiency during fetal life could attenuate normal cardiac functions in adult rats, an effect at least in part due to the increased expression of β-MHC to α- MHC ratio in the heart.
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