Evidence map›Paper›PMID 27411002›Full record

ArticleCell metabolism2016

Expanding Our Understanding of mtDNA Deletions.

Martin Picard, Amy E Vincent, Doug M Turnbull

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Maternal Inflammation During Pregnancy and Offspring Brain Development: The Role of Mitochondria.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022
    Review
  5. Cellular mechanisms of mtDNA heteroplasmy dynamics.Critical reviews in biochemistry and molecular biology · 2021
    Review
  6. Article
  7. Review
  8. The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Martin PicardDepartment of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY 10032, USA; Department of Neurology and Columbia Translational Neuroscience Initiative, H. Houston Merritt Center, Columbia University Medical Center, New York, NY 10032, USA; Wellcome Trust Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neurosciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Amy E VincentWellcome Trust Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neurosciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Doug M TurnbullWellcome Trust Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neurosciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Electronic address: doug.turnbull@newcastle.ac.uk.

Funding

Medical Research Council G0700718Medical Research Council G0800674Medical Research Council MC_G0802536Medical Research Council MR/L016354/1
6 · The paper itself

Abstract

Clonal expansion of mtDNA deletions compromises mitochondrial function in human disease and aging, but how deleterious mtDNA genomes propagate has remained unclear. In this issue (Gitschlag et al., 2016) and in a recent Nature publication, C. elegans studies implicate the mitochondrial unfolded protein response (UPR(mt)) and offer mechanistic insights into this process.

Indexed as

AgingAnimalsCaenorhabditis elegansDNA, MitochondrialHumansMitochondriaUnfolded Protein ResponseDNA, Mitochondrial

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.