SynthesisPloS one2016
Urinary Incontinence as a Predictor of Death: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The minimal important difference of patient-reported outcome measures related to female urinary incontinence: a systematic review.BMC medical research methodology · 2024Pooled it
- The impact of urinary incontinence on multiple health outcomes: an umbrella review of meta-analysis of observational studies.Aging clinical and experimental research · 2023Pooled it
- Heart rate variability dynamics in women with urinary incontinence: a systematic review.International urogynecology journal · 2022Pooled it
- Pooled it
- Urgency urinary incontinence, loss of independence, and increased mortality in older adults: A cohort study.PloS one · 2021Trial
- Article
- Knowledge, Attitudes, and Practices of Physiotherapists Regarding the Management of Urinary Incontinence in Elderly Patients in France: A Cross-Sectional Study.Lower urinary tract symptoms · 2025Article
- Association between urinary incontinence and mortality risk among US adults: a prospective cohort study.BMC public health · 2024Article
- Associations of overactive bladder (OAB) with suicidal ideation incidence and all-cause mortality among the U.S. population.BMC psychiatry · 2024Article
- A retrospective study on the prevalence and risk factors of neurogenic lower urinary tract dysfunction for acute ischemic stroke in China: A case-control study.Investigative and clinical urology · 2024Article
- The Relationship between Urinary Incontinence, Osteoarthritis, and Musculoskeletal System Disorders.Journal of clinical medicine · 2024Article
- Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function.International journal of colorectal disease · 2024Article
- Predictive Validity of the Johns Hopkins Fall Risk Assessment Tool for Older Patients in Stroke Rehabilitation.Healthcare (Basel, Switzerland) · 2024Article
- Pelvic floor therapy program for the treatment of female urinary incontinence in Belize: a pilot study.Frontiers in global women's health · 2024Article
- Incontinence during and following hospitalisation: a prospective study of prevalence, incidence and association with clinical outcomes.Age and ageing · 2023Article
- Cardiometabolic Disorders Are Important Correlates of Vulnerability in Hospitalized Older Adults.Nutrients · 2023Article
- Urinary incontinence in systemic sclerosis: a prospective multicentre cohort study.Rheumatology international · 2022Observational
- Factors associated with urinary and double incontinence in a geriatric post-hip fracture assessment in older women.Aging clinical and experimental research · 2022Article
- Comparison of Urinary Incontinence in Older White and Black Women: A Pilot Study.International journal of nursing and health care research · 2022Article
- Magnitude and Predictors of In-Hospital Stroke Mortality in Ethiopia: A Systematic Review and Meta-Analysis.Stroke research and treatment · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between urinary incontinence (UI) and increased mortality remains controversial. The objective of our study was to evaluate if this association exists.
methodsWe performed a systematic review and meta-analysis of observational studies comparing death rates among patients suffering from UI to those without incontinence. We searched in Medline, Embase and the Cochrane library using specific keywords. Studies exploring the post-stroke period were excluded. Hazard ratios (HR) were pooled using models with random effects. We stratified UI by gender and by UI severity and pooled all models with adjustment for confounding variables.
resultsThirty-eight studies were retrieved. When compared to non-urinary incontinent participants, UI was associated with an increase in mortality with pooled non adjusted HR of 2.22 (95%CI 1.77-2.78). The risk increased with UI severity: 1.24 (95%CI: 0.79-1.97) for light, 1.71 (95%CI: 1.26-2.31) for moderate, and 2.72 (95%CI: 1.90-3.87) for severe UI respectively. When pooling adjusted measures of association, the resulting HR was 1.27 (95%CI: 1.13-1.42) and increased progressively for light, moderate and severe UI: 1.07 (95%CI: 0.79-1.44), 1.25 (95%CI: 0.99-1.58), and 1.47 (95%CI: 1.03-2.10) respectively. There was no difference between genders.
conclusionUI is a predictor of higher mortality in the general and particularly in the geriatric population. The association increases with the severity of UI and persists when pooling models adjusted for confounders. It is unclear if this association is causative or just reflects an impaired general health condition. As in most meta-analyses of observational studies, methodological issues should be considered when interpreting results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.