Evidence map›Paper›PMID 27410749›Full record

ArticleBiophysical journal2016

Clathrin Assembly Regulated by Adaptor Proteins in Coarse-Grained Models.

Matteo Giani, Wouter K den Otter, Wim J Briels

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in immunology · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Matteo GianiMulti Scale Mechanics, Faculty of Engineering Technology, University of Twente, Enschede, The Netherlands; Computational BioPhysics, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands; MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.
Wouter K den OtterMulti Scale Mechanics, Faculty of Engineering Technology, University of Twente, Enschede, The Netherlands; Computational BioPhysics, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands; MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands. Electronic address: w.k.denotter@utwente.nl.
Wim J BrielsComputational BioPhysics, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands; MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands; Forschungszentrum Jülich, Jülich, Germany.
University of Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assembly of clathrin triskelia into polyhedral cages during endocytosis is regulated by adaptor proteins (APs). We explore how APs achieve this by developing coarse-grained models for clathrin and AP2, employing a Monte Carlo click interaction, to simulate their collective aggregation behavior. The phase diagrams indicate that a crucial role is played by the mechanical properties of the disordered linker segment of AP. We also present a statistical-mechanical theory for the assembly behavior of clathrin, yielding good agreement with our simulations and experimental data from the literature. Adaptor proteins are found to regulate the formation of clathrin coats under certain conditions, but can also suppress the formation of cages.

Indexed as

Models, MolecularAdaptor Proteins, Signal TransducingClathrinMonte Carlo MethodProtein ConformationAdaptor Proteins, Signal TransducingClathrin

Identifiers

PMID27410749
PMCPMC4944722
OpenAlexW2461898700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.