Evidence map›Paper›PMID 27410497›Full record

ArticleAIDS patient care and STDs2016

Adolescent Human Immunodeficiency Virus Care Providers' Attitudes Toward the Use of Oral Pre-Exposure Prophylaxis in Youth.

Tanya L Kowalczyk Mullins, Gregory Zimet, Michelle Lally, Jessica A Kahn

Open access · greenAbstract read
In one paragraph

Article in AIDS patient care and STDs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  15. Social-Ecological Barriers to Access to Healthcare for Adolescents: A Scoping Review.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tanya L Kowalczyk Mullins1 Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.
Gregory Zimet3 Division of Adolescent Medicine, Indiana University , Indianapolis, Indiana.
Michelle Lally4 Division of Infectious Diseases, Department of Medicine, Lifespan Hospital System/Alpert Medical School of Brown University , Providence, Rhode Island.
Jessica A Kahn1 Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center · USIndiana University – Purdue University Indianapolis · USProvidence College · US

Funding

Adol. Medicine Trials Network for HIV/AIDS InterventionsU01HD040474 · NICHD · WESTAT, INC. · PI HARRIS, DONALD ROBERT · 2001 to 2016
$114.4M
LEADERSHIP GROUP FOR ADOLESCENT MEDICINE TRIALS NETWORKU01HD040533 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, CRAIG M · 2001 to 2016
$76.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Physician Attitudes toward New Biomedical HIV Prevention Interventions in YouthK23HD072807 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI MULLINS, TANYA L. KOWALCZYK · 2013 to 2017
$651k
NCATS NIH HHS UL1 TR001425NIAID NIH HHS P30 AI042853NICHD NIH HHS K23 HD072807NICHD NIH HHS U01 HD040474NICHD NIH HHS U01 HD040533
6 · The paper itself

Abstract

Oral pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) prevention is currently indicated for use in adults in the United States and may soon be indicated for minor adolescents. However, implementation of PrEP use among minors may present unique barriers. We conducted 15 individual, semi-structured interviews among US clinicians caring for HIV-infected and at-risk youth. The theory-driven interview guide assessed demographics, perceived role of oral PrEP in HIV prevention among adolescents, perceived barriers to and facilitating factors for use of PrEP in adolescents, and clinician-reported likelihood of prescribing PrEP. Transcripts were analyzed using framework analysis. Overall, clinicians viewed PrEP as a time-limited intervention that is one part of a comprehensive approach to HIV prevention among adolescents. Perceived barriers to prescribing to minors included concerns about: confidentiality, legality of minors consenting to PrEP without parental involvement, ability of minors to understand the risks/benefits of PrEP, the possible impact of PrEP on bone accrual, off-label use of PrEP medication in minors, and the high costs associated with PrEP use. Clinician-reported facilitating factors for prescribing PrEP to youth included educating communities and other clinicians about PrEP, ensuring adequate financial resources and infrastructure for delivering PrEP, developing formal guidance on effective behavioral interventions that should be delivered with PrEP, and gaining personal experience with prescribing PrEP. Clinicians indicated greater comfort with prescribing PrEP to adults versus minors. For PrEP to become more widely available to youth at risk for HIV infection, barriers that are unique to PrEP use in minors must be addressed.

Indexed as

Attitude of Health PersonnelHealth Knowledge, Attitudes, PracticeAdolescentAdultAnti-HIV AgentsFemaleHealth EducationHealth PersonnelHIV InfectionsHumansInterviews as TopicMalePerceptionPre-Exposure ProphylaxisQualitative ResearchSafe SexAnti-HIV Agents

Identifiers

PMID27410497
PMCPMC4948218
OpenAlexW2499060639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.