ArticleRevista Brasileira de terapia intensiva2016
Drug incompatibilities in the adult intensive care unit of a university hospital.
Article in Revista Brasileira de terapia intensiva, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools.European journal of clinical pharmacology · 2026Observational
- FIRST-ICU: forecasting interventions and risk stratification in the ICU using graph neural network autoencoders.NPJ digital medicine · 2026Article
- Physicochemical compatibility and stability of ketamine co-administered with selected supportive care drugs and parenteral nutrition in pediatric oncology.Exploratory research in clinical and social pharmacy · 2026Article
- In Vitro Evaluation of the Compatibility of Meropenem and Tanreqing Under Parallel Infusion Conditions.Pharmaceutics · 2026Article
- Clinical pharmacist-led prevention of intravenous drug incompatibilities in an adult ICU: a prospective observational study.BMC pharmacology & toxicology · 2026Observational
- Compatibility and Stability Study of Butorphanol, Nicardipine, Urapidil, and Tirofiban During Multidrug Simultaneous Infusion.Drug design, development and therapy · 2026Article
- Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors.Drug design, development and therapy · 2024Article
- Analysis of the Integrated Management Model of Medical Care and Medication in Intravenous Treatment for Critically Ill Patients.Journal of multidisciplinary healthcare · 2024Article
- Avoiding incompatible drug pairs in central-venous catheters of patients receiving critical care: an algorithm-based analysis and a staff survey.European journal of clinical pharmacology · 2023Article
- Implementation of pharmacists' monitoring for intravenous drug compatibility.European journal of hospital pharmacy : science and practice · 2023Article
- Y-Site Compatibility Studies of Ketoprofen with Parenteral Nutrition Admixtures for Central and Peripheral Administration.Pharmaceutics · 2022Article
- Drug incompatibilities in intravenous therapy: evaluation and proposition of preventive tools in intensive care and hematology units.European journal of clinical pharmacology · 2019Observational
- Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities.Scientific reports · 2017Article
- Intravenous Drug Incompatibilities in the Intensive Care Unit of a Tertiary Care Hospital in India: Are they Preventable?Journal of research in pharmacy practiceArticle
- Evaluation of Incompatible Coadministration of Continuous Intravenous Infusions in a Pediatric/Neonatal Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study sought to identify the physical and chemical incompatibilities among the drugs administered intravenously to patients admitted to an adult intensive care unit. We also aimed to establish pharmaceutical guidelines for administering incompatible drugs.
methodsThis cross-sectional, prospective, and quantitative study was conducted from July to September 2015. Drug incompatibilities were identified based on an analysis of the patient prescriptions available in the hospital online management system. A pharmaceutical intervention was performed using the guidelines on the preparation and administration of incompatible drugs. Adherence to those guidelines was subsequently assessed among the nursing staff.
resultsA total of 100 prescriptions were analyzed; 68 were incompatible with the intravenous drugs prescribed. A total of 271 drug incompatibilities were found, averaging 4.0 ± 3.3 incompatibilities per prescription. The most commonly found drug incompatibilities were between midazolam and hydrocortisone (8.9%), between cefepime and midazolam (5.2%), and between hydrocortisone and vancomycin (5.2%). The drugs most commonly involved in incompatibilities were midazolam, hydrocortisone, and vancomycin. The most common incompatibilities occurred when a drug was administered via continuous infusion and another was administered intermittently (50%). Of the 68 prescriptions that led to pharmaceutical guidelines, 45 (66.2%) were fully adhered to by the nursing staff.
conclusionPatients under intensive care were subjected to a high rate of incompatibilities. Drug incompatibilities can be identified and eliminated by the pharmacist on the multidisciplinary team, thereby reducing undesirable effects among patients.
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