ArticleOrganic letters2016
KetoABNO/NOx Cocatalytic Aerobic Oxidation of Aldehydes to Carboxylic Acids and Access to α-Chiral Carboxylic Acids via Sequential Asymmetric Hydroformylation/Oxidation.
Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A reflection on ketoABNO: the crossing point between organic synthesis and protein modification.Chemical science · 2025Article
- The Al-Containing Silicates Modified with Organic Ligands and SnONanomaterials (Basel, Switzerland) · 2023Article
- A cobalt adduct of an N-hydroxy-piperidinium cation.Journal of coordination chemistry · 2022Article
- Article
- Aminoxyl-Catalyzed Electrochemical Diazidation of Alkenes Mediated by a Metastable Charge-Transfer Complex.Journal of the American Chemical Society · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
A method for aerobic oxidation of aldehydes to carboxylic acids has been developed using organic nitroxyl and NOx cocatalysts. KetoABNO (9-azabicyclo[3.3.1]nonan-3-one N-oxyl) and NaNO2 were identified as the optimal nitroxyl and NOx sources, respectively. The mildness of the reaction conditions enables sequential asymmetric hydroformylation of alkenes/aerobic aldehyde oxidation to access α-chiral carboxylic acids without racemization. The scope, utility, and limitations of the oxidation method are further evaluated with a series of achiral aldehydes bearing diverse functional groups.
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