ArticleProceedings of the National Academy of Sciences of the United States of America2016
Allosteric proteins as logarithmic sensors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Habituation as optimal filtering.iScience · 2024Article
- A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions.NPJ systems biology and applications · 2023Article
- A negative feedback loop in the GPCR pathway underlies efficient coding of external stimuli.Molecular systems biology · 2022Article
- Molecular switch architecture determines response properties of signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Free testosterone and cardiometabolic parameters in men: comparison of algorithms.Endocrine connections · 2021Article
- SNAPS: Sensor Analytics Point Solutions for Detection and Decision Support Systems.Sensors (Basel, Switzerland) · 2019Review
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- Communication codes in developmental signaling pathways.Development (Cambridge, England) · 2019Review
- Detection of persistent signals and its relation to coherent feed-forward loops.Royal Society open science · 2018Article
- Signaling pathways as linear transmitters.eLife · 2018Article
- A biochemical logarithmic sensor with broad dynamic range.F1000Research · 2018Article
- Identifiability, reducibility, and adaptability in allosteric macromolecules.The Journal of general physiology · 2017Article
- Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.The journal of physical chemistry. B · 2017Article
- Cross-hierarchy systems principles.Current opinion in systems biology · 2017Article
- Chemical reaction networks for computing logarithm.Synthetic biology (Oxford, England) · 2017Article
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2 authors.
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Abstract
Many sensory systems, from vision and hearing in animals to signal transduction in cells, respond to fold changes in signal relative to background. Responding to fold change requires that the system senses signal on a logarithmic scale, responding identically to a change in signal level from 1 to 3, or from 10 to 30. It is an ongoing search in the field to understand the ways in which a logarithmic sensor can be implemented at the molecular level. In this work, we present evidence that logarithmic sensing can be implemented with a single protein, by means of allosteric regulation. Specifically, we find that mathematical models show that allosteric proteins can respond to stimuli on a logarithmic scale. Next, we present evidence from measurements in the literature that some allosteric proteins do operate in a parameter regime that permits logarithmic sensing. Finally, we present examples suggesting that allosteric proteins are indeed used in this capacity: allosteric proteins play a prominent role in systems where fold-change detection has been proposed. This finding suggests a role as logarithmic sensors for the many allosteric proteins across diverse biological processes.
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