ArticleNature2016
A comprehensive transcriptional map of primate brain development.
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In one paragraph
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 1 pooled it
27.9field-weighted citation impact, top 1% of its field
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Who cites it
223 citing papers in PubMed, 1 synthesis or guideline pooled it, 401 citations in OpenAlex.
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- Relationship Between Dp140 Genotype and Cortical Similarity Network Phenotype in Duchenne Muscular Dystrophy: Preliminary T1 Weighted Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis.The EMBO journal · 2026Article
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- Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons.Journal of anatomy · 2026Article
- Advances in the Comprehensive Tree Shrew Brain Atlas.Biomolecules · 2026Review
- Positive selection on brain cis-regulatory elements in the human lineage drives changes in gene expression and susceptibility to neuropsychiatric disorders.HGG advances · 2026Article
- Brain Spatial Genomics Atlases.Genes · 2026Review
- Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.Translational psychiatry · 2026Article
- Modeling striatal development and disease with human pluripotent stem cells.Inflammation and regeneration · 2026Review
- Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.Nature communications · 2026Article
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.Genome biology and evolution · 2026Article
- NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development.Nature neuroscience · 2026Article
- Genetically Modified Primate Models for Brain Disorder Research.Neuroscience bulletin · 2026Review
- Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex.Nature neuroscience · 2026Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
99 authors at 6 institutions in 2 countries.
Trygve E BakkenAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jeremy A MillerAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Song-Lin DingAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Kimberly A SmithAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Lydia NgAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Rachel A DalleyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Joshua J RoyallAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Tracy LemonAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Sheila ShapouriAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Kaylynn AionaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
James ArnoldAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jeffrey L BennettDepartment of Psychiatry and Behavioral Science, California National Primate Research Center, The M.I.N.D. Institute, University of California, Davis, Sacramento, California 95817, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Kristopher BickleyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Andrew BoeAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Stephanie ButlerAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Emi ByrnesAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Shiella CaldejonAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Anita CareyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Shelby CateAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Mike ChapinAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jefferey ChenAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Nick DeeAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Tsega DestaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Tim A DolbeareAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Nadia DotsonAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Amanda EbbertAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Erich FulfsAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Garrett GeeAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Terri L GilbertAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Lindsey GourleyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Ben GregorAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Guangyu GuAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jon HallAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Zeb HaradonAllen Institute for Brain Science, Seattle, Washington 98109, USA.
David R HaynorDepartment of Radiology, University of Washington, Seattle, Washington 98195, USA.
Nika HejaziniaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Robert HowardAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jay JochimAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Marty KinnunenAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Ali KriedbergAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Chihchau L KuanAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Christopher LauAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Chang-Kyu LeeAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Felix LeeAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Lon LuongAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Naveed MastanAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Ryan MayAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jose MelchorAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Nerick MosquedaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Erika MottAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Julie NyhusAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Aaron OldreAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Eric OlsonAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jody ParenteAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Patrick D ParkerAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Sheana ParryAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Julie PendergraftAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Lydia PotekhinaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Melissa RedingAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Zackery L RileyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Tyson RobertsAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Brandon RogersAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Kate RollAllen Institute for Brain Science, Seattle, Washington 98109, USA.
David RosenAllen Institute for Brain Science, Seattle, Washington 98109, USA.
David SandmanAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Melaine SarrealAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Nadiya ShapovalovaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Shu ShiAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Nathan SjoquistAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Andy J SodtAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Robbie TownsendAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Lissette VelasquezAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Udi WagleyAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Wayne B WakemanAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Cassandra WhiteAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Crissa BennettAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Jennifer WuAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Rob YoungAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Brian L YoungstromAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Paul WohnoutkaAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Richard A GibbsHuman Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Jeffrey RogersHuman Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
John G HohmannAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Robert F HevnerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98101, USA.
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
John W PhillipsAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Chinh DangAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Allan R JonesAllen Institute for Brain Science, Seattle, Washington 98109, USA.
David G AmaralDepartment of Psychiatry and Behavioral Science, California National Primate Research Center, The M.I.N.D. Institute, University of California, Davis, Sacramento, California 95817, USA.
Amy BernardAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, Washington 98109, USA.
Allen Institute · USAllen Institute for Brain Science · USBaylor College of Medicine · USUniversity of California, Davis · USUniversity of Oxford · GBUniversity of Washington · US
Funding
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2MMedical Research Council G0500180Medical Research Council G0700377Medical Research Council MR/N026039/1NCRR NIH HHS P51 RR000169NCRR NIH HHS RR00169NIMH NIH HHS HHSN271200800047C
Abstract
The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.
Indexed as
TranscriptomeAgingAnimalsAutism Spectrum DisorderBrainCell AdhesionConserved SequenceFemaleHumansIntellectual DisabilityMacaca mulattaMaleMicrocephalyNeocortexNeurodevelopmental DisordersNeurogenesis
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