ArticleNutrients2016
Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species.Nutrients · 2020Pooled it
- Trial
- Article
- Mechanistic Research on the Crosstalk Between Macrophage Polarization and Energy Metabolic Reprogramming in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Review
- Histidine-Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Article
- Relationships of Upper respiratory tract infections and holistic diets and lifestyles in Northeast China.BMC nutrition · 2025Article
- Rapid exometabolome footprinting combined with multivariate statistics: A powerful tool for bioprocess optimization.Engineering in life sciences · 2025Article
- Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases.Life (Basel, Switzerland) · 2024Review
- The inverse associations of glycine and histidine in diet with hyperlipidemia and hypertension.Nutrition journal · 2024Article
- Proteomics and metabolomics analyses of urine for investigation of gallstone disease in a high-altitude area.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Light-responsive adipose-hypothalamus axis controls metabolic regulation.Nature communications · 2024Article
- Article
- Untargeted metabolomic analysis investigating links between unprocessed red meat intake and markers of inflammation.The American journal of clinical nutrition · 2023Article
- Association between Health Literacy and Prevalence of Obesity, Arterial Hypertension, and Diabetes Mellitus.International journal of environmental research and public health · 2022Article
- Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement.Nutrients · 2020Review
- Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.Nutrients · 2020Review
- The prevalence and increasing trends of overweight, general obesity, and abdominal obesity among Chinese adults: a repeated cross-sectional study.BMC public health · 2019Article
- Association between dietary intake and inflammatory markers: results from the CoLaus study.Public health nutrition · 2019Article
- Associations of dietary phytosterols with blood lipid profiles and prevalence of obesity in Chinese adults, a cross-sectional study.Lipids in health and disease · 2018Article
- Dietary Components and Metabolic Dysfunction: Translating Preclinical Studies into Clinical Practice.Nutrients · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous studies have demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women and high-fat diet-induced obese rats. However, the effects of dietary histidine on general population are not known. The objective of this Internet-based cross-sectional study was to evaluate the associations between dietary histidine and prevalence of overweight/obesity and abdominal obesity in northern Chinese population. A total of 2376 participants were randomly recruited and asked to finish our Internet-based dietary questionnaire for the Chinese (IDQC). Afterwards, 88 overweight/obese participants were randomly selected to explore the possible mechanism. Compared with healthy controls, dietary histidine was significantly lower in overweight (p < 0.05) and obese (p < 0.01) participants of both sexes. Dietary histidine was inversely associated with body mass index (BMI), waist circumference (WC) and blood pressure in overall population and stronger associations were observed in women and overweight/obese participants. Higher dietary histidine was associated with lower prevalence of overweight/obesity and abdominal obesity, especially in women. Further studies indicated that higher dietary histidine was associated with lower fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-h postprandial glucose (2 h-PG), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), malonaldehyde (MDA) and vaspin and higher glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and adiponectin of overweight/obese individuals of both sexes. In conclusion, higher dietary histidine is inversely associated with energy intake, status of insulin resistance, inflammation and oxidative stress in overweight/obese participants and lower prevalence of overweight/obesity in northern Chinese adults.
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