ArticleInvestigative ophthalmology & visual science2016
Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Integrated visible-light optical coherence tomography and fluorescence scanning laser ophthalmoscopy to image retinal ganglion cell axons.Biomedical optics express · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis.Heliyon · 2024Article
- Detection of Choroidal Neovascularization Using Optical Tissue Transparency.Translational vision science & technology · 2023Article
- Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.Translational vision science & technology · 2021Article
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Retinopathy of prematurity and neonatal gut microbiome: An interview with Professor Dimitra Skondra, Associate Professor of Ophthalmology and Vitreoretinal Surgeon at The University of Chicago (USA).Experimental and therapeutic medicine · 2020Article
- Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.Cell death & disease · 2020Article
- Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model.Translational vision science & technology · 2020Article
- Inhibition of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor by Chrysin in a Rat Model of Choroidal Neovascularization.International journal of molecular sciences · 2020Article
- Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes.Investigative ophthalmology & visual science · 2020Article
- Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser.Biomedical optics express · 2019Article
- Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation.Biomedical optics express · 2018Article
- Assessment of pathological features in Alzheimer's disease brain tissue with a large field-of-view visible-light optical coherence microscope.Neurophotonics · 2018Article
- Article
- Volumetric fluorescence retinal imagingBiomedical optics express · 2018Article
- Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017Review
- Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT.Biomedical optics express · 2017Article
- OCT angiography and visible-light OCT in diabetic retinopathy.Vision research · 2017Review
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7 authors.
Funding
Abstract
purposeThis study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV.
methodsVisible light-OCTA was used to study laser-induced CNV at different time-points after laser injury to monitor CNV development and measure CNV lesion size. Measurements obtained from vis-OCTA angiograms were compared with histopathologic measurements from isolectin-stained choroidal flatmounts.
resultsChoroidal neovascularization area measurements between the vis-OCTA system and isolectin-stained choroidal flatmounts were significantly different in area for days 2 to 4 postlaser injury, and were not significantly different in area for days 5, 7, and 14. Choroidal neovascularization area measurements taken from the stained flatmounts were larger than their vis-OCTA counterparts for all time-points. Both modalities showed a similar trend of CNV size increasing from the day of laser injury until a peak of day 7 postlaser injury and subsequently decreasing by day 14.
conclusionsThe earliest vis-OCTA can detect the presence of aberrant vessels in a mouse laser-induced CNV model is 5 days after laser injury. Visible light-OCTA was able to visualize the maximum of the CNV network 7 days postlaser injury, in accordance with choroidal flatmount immunostaining. Visible light-OCTA is a reliable tool in both detecting the presence of CNV development, as well as accurately determining the size of the lesion in a mouse laser-induced CNV model.
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