ArticleInvestigative ophthalmology & visual science2016
In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models.Investigative ophthalmology & visual science · 2023Article
- The Curvature, Collagen Network Structure, and Their Relationship to the Pressure-Induced Strain Response of the Human Lamina Cribrosa in Normal and Glaucoma Eyes.Journal of biomechanical engineering · 2023Article
- Neuroretinal Rim Response to Transient Intraocular Pressure Challenge Predicts the Extent of Retinal Ganglion Cell Loss in Experimental Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation.Translational vision science & technology · 2023Article
- Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma.Translational vision science & technology · 2022Article
- A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography.Acta biomaterialia · 2022Article
- Comparison of Corneal Wave Speed and Ocular Rigidity in Normal and Glaucomatous Eyes.Journal of glaucoma · 2021Article
- Mechanical Strain Regulates Myofibroblast Differentiation of Human Scleral Fibroblasts by YAP.Frontiers in physiology · 2021Article
- Biomechanics of the optic nerve head and peripapillary sclera in a mouse model of glaucoma.Journal of the Royal Society, Interface · 2020Article
- Optic Nerve Head Morphological Changes Over 12 Hours in Seated and Head-Down Tilt Postures.Investigative ophthalmology & visual science · 2020Article
- The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa.Investigative ophthalmology & visual science · 2020Article
- Neuroretinal rim response to transient changes in intraocular pressure in healthy non-human primate eyes.Experimental eye research · 2020Article
- The Dynamic Scleral Extracellular Matrix Alterations in Chronic Ocular Hypertension Model of Rats.Frontiers in physiology · 2020Article
- Article
- The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model.Investigative ophthalmology & visual science · 2019Article
- Morphological and functional changes in the rat retina associated with 2 months of intermittent moderate intraocular pressure elevation.Scientific reports · 2018Article
- Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.Investigative ophthalmology & visual science · 2018Article
- The effects of graded intraocular pressure challenge on the optic nerve head.Experimental eye research · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo compare optical coherence tomography (OCT) detected, optic nerve head (ONH) compliance within control and experimental glaucoma (EG) eyes of 15 monkeys at EG onset.
methodsIntraocular pressure (IOP) was chronically elevated in one eye of each animal using a laser. Experimental glaucoma onset was identified using confocal scanning laser tomography (CSLT). Optical coherence tomography ONH imaging (40 radial B-scans) was performed at 10 mm Hg before and after laser. At EG onset, OCT scans were obtained at IOP 10 and 30 mm Hg. Optical coherence tomography landmarks within the IOP 10/30 images were delineated to quantify IOP 10/30 differences (compliance) for anterior lamina cribrosa surface depth (ALCSD) relative to Bruch's membrane opening (BMO) (ALCSD-BMO), ALCSD relative to peripheral BM (ALCSD-BM), and BMO depth relative to peripheral BM (BMOD-BM). A linear mixed effects model assessed for acute IOP elevation effects, control versus EG eye effects, and their interaction.
resultsEffects of IOP elevation were greater in EG versus control eyes for ALCSD-BMO (-46 ± 45 vs. -8 ± 13 μm, P = 0.0042) and ALCSD-BM (-92 ± 64 vs. -42 ± 22 μm, P = 0.0075). Experimental glaucoma eye-specific ALCSD-BMO and ALCSD-BM compliance exceeded the range of control eye compliance in 9 and 8 of the 15 EG eyes, respectively. Post-laser peak IOP (R2 = 0.798, P < 0.0001) and post-laser mean IOP (R2 = 0.634, P < 0.0004) most strongly correlated to EG versus control eye differences in ALCSD-BMO compliance.
conclusionsLaminar (ALCSD-BMO) and peripapillary scleral (ALCSD-BM) hypercompliance are present in most monkey eyes at the onset of EG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.