ArticleInvestigative ophthalmology & visual science2016
Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy.Scientific reports · 2024Article
- Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats.Investigative ophthalmology & visual science · 2022Article
- Peripapillary Vascular Reactivity in Primary Open-Angle Glaucoma With High Myopia by Using Optical Coherence Tomography Angiography.Frontiers in medicine · 2022Article
- Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2021Article
- Variability of Retinal Oxygen Metrics in Healthy and Diabetic Subjects.Translational vision science & technology · 2021Article
- OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.Ophthalmology. Retina · 2018Article
- Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects.Investigative ophthalmology & visual science · 2018Article
- Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography.The British journal of ophthalmology · 2018Article
- Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina.Journal of ophthalmic & vision researchArticle
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Authors and funding
7 authors.
Funding
Abstract
purposeTo use multiplane en face Doppler optical coherence tomography (OCT) to measure the change in total retinal blood flow (TRBF) in response to hyperoxia.
methodsOne eye of each healthy human participant (n = 8) was scanned with a commercial high-speed (70-kHz) spectral OCT system. Three repeated scans were captured at baseline and after 10 minutes of oxygen (hyperoxia) by open nasal mask. The procedure was performed twice on day 1 and once more on day 2. Blood flow of each vein was estimated using Doppler OCT at an optimized en face plane. The TRBF was summed from all veins at the optic disc. The TRBF hyperoxic response was calculated as the TRBF percent change from baseline.
resultsParticipants experienced a 23.6% ± 10.7% (mean ± standard deviation [SD]) decrease (P < 0.001, paired t-test) in TRBF during hyperoxia. The within-day repeatability of baseline TRBF was 4.1% and the between-day reproducibility was 10.9% coefficient of variation (CV). Between-grader reproducibility was 3.9% CV. The repeatability and reproducibility (pooled SD) of hyperoxic response were 6.1% and 6.4%, respectively.
conclusionsThe multiplane en face Doppler OCT algorithm was able to detect, in all participants, a decreased TRBF in response to hyperoxia. The response magnitude for each participant varied among repeated trials, and the averaging of multiple trials was helpful in establishing the individual response. This technique shows good potential for the clinical investigation of vascular autoregulation.
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