ArticleInvestigative ophthalmology & visual science2016
Evaluating the Effects of Riboflavin/UV-A and Rose-Bengal/Green Light Cross-Linking of the Rabbit Cornea by Noncontact Optical Coherence Elastography.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 46 citations in OpenAlex.
- Wavelet time-frequency analysis enhances noise-resilient quantification of corneal wave velocity and natural frequency in optical coherence elastography.Biomedical optics express · 2026Article
- Rose Bengal-Assisted Photodynamic Antimicrobial Therapy for Keratitis.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025Article
- Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.Biomedical optics express · 2025Article
- Corneal Resistance to Enzymatic Digestion After Rose Bengal and Combined Rose Bengal/Riboflavin Cross-Linking Is Oxygen Independent.Translational vision science & technology · 2025Article
- Quantitative assessment of corneal biomechanical changes in vivo after photorefractive intrastromal corneal cross-linking using optical coherence elastography.Quantitative imaging in medicine and surgery · 2024Article
- Effects of Different Scleral Photo-Crosslinking Modalities on Scleral Stiffness and Hydration.Investigative ophthalmology & visual science · 2024Article
- Effect of accelerated high-fluence riboflavin and rose bengal-mediated corneal cross-linking on resistance to enzymatic digestion.BMC ophthalmology · 2024Article
- Combining Riboflavin/UV-A Light and Rose Bengal/Green Light Corneal Cross-Linking Increases the Resistance of Corneal Enzymatic Digestion.Translational vision science & technology · 2024Article
- How Modifications of Corneal Cross-Linking Protocols Influence Corneal Resistance to Enzymatic Digestion and Treatment Depth.Translational vision science & technology · 2023Article
- In Vivo Evaluation of the Effects of SMILE with Different Amounts of Stromal Ablation on Corneal Biomechanics by Optical Coherence Elastography.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Assessing corneal cross-linking with reverberant 3D optical coherence elastography.Journal of biomedical optics · 2022Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Mechanical behaviour of healthy versus alkali-lesioned corneas by a porcine organ culture model.BMC veterinary research · 2021Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography.Journal of biomedical optics · 2020Article
- Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration.Translational vision science & technology · 2020Article
- Ultrahigh-sensitive optical coherence elastography.Light, science & applications · 2020Article
- In-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography.Biomedical optics express · 2019Article
- Advances in Doppler optical coherence tomography and angiography.Translational biophotonics · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThe purpose of this study was to use noncontact optical coherence elastography (OCE) to evaluate and compare changes in biomechanical properties that occurred in rabbit cornea in situ after corneal collagen cross-linking by either of two techniques: ultraviolet-A (UV-A)/riboflavin or rose-Bengal/green light.
methodsLow-amplitude (≤10 μm) elastic waves were induced in mature rabbit corneas by a focused air pulse. Elastic wave propagation was imaged by a phase-stabilized swept source OCE (PhS-SSOCE) system. Corneas were then cross-linked by either of two methods: UV-A/riboflavin (UV-CXL) or rose-Bengal/green light (RGX). Phase velocities of the elastic waves were fitted to a previously developed modified Rayleigh-Lamb frequency equation to obtain the viscoelasticity of the corneas before and after the cross-linking treatments. Micro-scale depth-resolved phase velocity distribution revealed the depth-wise heterogeneity of both cross-linking techniques.
resultsUnder standard treatment settings, UV-CXL significantly increased the stiffness of the corneas by ∼47% (P < 0.05), but RGX did not produce statistically significant increases. The shear viscosities were unaffected by either cross-linking technique. The depth-wise phase velocities showed that UV-CXL affected the anterior ∼34% of the corneas, whereas RGX affected only the anterior ∼16% of the corneas.
conclusionsUV-CXL significantly strengthens the cornea, whereas RGX does not, and the effects of cross-linking by UV-CXL reach deeper into the cornea than cross-linking effects of RGX under similar conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.