Evidence map›Paper›PMID 27409343›Full record

ArticleOncotarget2016

Independent evaluation of a FOXM1-based quantitative malignancy diagnostic system (qMIDS) on head and neck squamous cell carcinomas.

Hong Ma, Haiyan Dai, Xiaofeng Duan, Zhenglong Tang, Rui Liu, Kunjun Sun, Ke Zhou, Hao Chen, Hang Xiang, Jinsheng Wang and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Hong MaChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Haiyan DaiChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Xiaofeng DuanChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Zhenglong TangChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Rui LiuChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Kunjun SunChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Ke ZhouChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Hao ChenChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Hang XiangChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Jinsheng WangChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Qiong GaoChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Yuan ZouChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Hong WanChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Muy-Teck TehChina-British Joint Molecular Head and Neck Cancer Research Laboratory, Department of Oral and Maxillofacial Surgery, Hospital and School of Stomatology, Guizhou Medical University, Guizhou, China.
Guiyang Medical University · CNQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The forkhead box M1 (FOXM1) transcription factor gene has been implicated in almost all human cancer types. It would be an ideal biomarker for cancer detection but, to date, its translation into a cancer diagnostic tool is yet to materialise. The quantitative Malignancy Index Diagnostic System (qMIDS) was the first FOXM1 oncogene-based diagnostic test developed for quantifying squamous cell carcinoma aggressiveness. The test was originally validated using head and neck squamous cell carcinomas (HNSCC) from European patients. The HNSCC gene expression signature across geographical and ethnic differences is unknown. This is the first study evaluated the FOXM1-based qMIDS test using HNSCC specimens donated by ethnic Chinese patients. We tested 50 Chinese HNSCC patients and 18 healthy subjects donated 68 tissues in total. qMIDS scores from the Chinese cohort were compared with the European datasets (n = 228). The median ± SD scores for the Chinese cohort were 1.13 ± 0.66, 4.02 ± 1.66 and 5.83 ± 3.13 in healthy oral tissues, adjacent tumour margin and HNSCC core tissue, respectively. Diagnostic test efficiency between the Chinese and European datasets was almost identical. Consistent with previous European data, qMIDS scores for HNSCC samples were not influenced by gender or age. The degree of HNSCC differentiation, clinical stage and lymphatic metastasis status were found to be correlated with qMIDS scores. This study provided the first evidence that the pathophysiology of HNSCC was molecularly indistinguishable between the Chinese and European specimens. The qMIDS test robustly quantifies a universal FOXM1-driven oncogenic program, at least in HNSCC, which transcends ethnicity, age, gender and geographic origins.

Indexed as

AdultAgedCarcinoma, Squamous CellFemaleForkhead Box Protein M1Head and Neck NeoplasmsHumansMaleMiddle AgedOncogenesSquamous Cell Carcinoma of Head and NeckForkhead Box Protein M1FOXM1 protein, humanearly cancer biomarkersethnicityFOXM1molecular diagnosticssquamous cell carcinoma

Identifiers

PMID27409343
PMCPMC5342363
OpenAlexW2461937672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.