Evidence map›Paper›PMID 27408799›Full record

ArticleNeuroImage. Clinical2016

Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals.

Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Ketura Berry, Chiara Muratori, Stefano Ferracuti, Paolo Roma and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. EEG event related potentials in sustained, focused and divided attention tasks: Potential biomarkers for cognitive impairment in HIV patients.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 1 country.

Claudio BabiloniDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS S. Raffaele Pisana, Rome, Italy.
Alfredo PennicaInfectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Claudio Del PercioIRCCS SDN, Naples, Italy.
Giuseppe NoceIRCCS SDN, Naples, Italy.
Susanna CordoneDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
Susanna LopezDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
Ketura BerryDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
Chiara MuratoriIRCCS S. Raffaele Pisana, Rome, Italy.
Stefano FerracutiPsychiatry, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Paolo RomaPsychiatry, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Valentina CorrerPsychiatry, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Francesco Di CampliInfectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Laura GianserraInfectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Lorenzo CiulliniInfectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Antonio AcetiInfectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy.
Andrea SoricelliIRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
Elisabetta TetiClinical Infectious Diseases, University of Rome "Tor Vergata", Rome, Italy.
Magdalena ViscioneClinical Infectious Diseases, University of Rome "Tor Vergata", Rome, Italy.
Cristina LimatolaDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
Paolo OnoratiDepartment of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS S. Raffaele Pisana, Rome, Italy.
Paolo CapotostoITAB, University of Chieti "D'Annunzio", Chieti, Italy.
Massimo AndreoniClinical Infectious Diseases, University of Rome "Tor Vergata", Rome, Italy.
Sapienza University of Rome · ITIRCCS Ospedale San Raffaele · ITUniversity of Rome Tor Vergata · ITSDN Istituto di Ricerca Diagnostica e Nucleare · ITIstituto Neurologico Mediterraneo · ITParthenope University of Naples · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHere we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals.

methodsResting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13-20 Hz) and beta2 (20-30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions.

resultsBefore the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p < 0.05). After 5 months of cART, delta source activity decreased, and alpha3 source activity increased in the HIV subjects with EEG + (about 50% of them showed a normalized EEG marker).

conclusionsThis procedure detected a deviant EEG marker before therapy and its post-therapy normalization in naïve HIV single individuals. SIGNIFICANCE: The parietal delta/alpha3 EEG marker may be used to monitor cART effects on brain function in such individuals.

Indexed as

Antiretroviral Therapy, Highly ActiveAdultAlpha RhythmBeta RhythmBrain WavesCerebral CortexDelta RhythmElectroencephalographyHIV InfectionsHumansMaleAlpha rhythmsDelta rhythmsHuman immunodeficiency virus (HIV)Low-resolution brain electromagnetic source tomography (LORETA)Resting-state electroencephalography (EEG)z-Score

Identifiers

PMID27408799
PMCPMC4933036
OpenAlexW2413928921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.