ArticleNeuroImage. Clinical
Connectome-scale assessment of structural and functional connectivity in mild traumatic brain injury at the acute stage.
Article in NeuroImage. Clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- Symptom Persistence Relates to Volume and Asymmetry of the Limbic System after Mild Traumatic Brain Injury.Journal of clinical medicine · 2024Article
- Identification and Connectomic Profiling of Concussion Using Bayesian Machine Learning.Journal of neurotrauma · 2024Article
- Graph Analysis of the Visual Cortical Network during Naturalistic Movie Viewing Reveals Increased Integration and Decreased Segregation Following Mild TBI.Vision (Basel, Switzerland) · 2024Article
- Prediction of cognitive outcome after mild traumatic brain injury from acute measures of communication within brain networks.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- The Relationship Between Cortical Morphological and Functional Topological Properties and Clinical Manifestations in Patients with Posttraumatic Diffuse Axonal Injury: An Individual Brain Network Study.Brain topography · 2023Article
- Extracting functional connectivity brain networks at the resting state from pulsed arterial spin labeling data.Meta-radiology · 2023Article
- Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.Brain : a journal of neurology · 2023Article
- Alzheimer's Disease-Related Dementias Summit 2022: National Research Priorities for the Investigation of Post-Traumatic Brain Injury Alzheimer's Disease and Related Dementias.Journal of neurotrauma · 2023Article
- Diffusion in the corpus callosum predicts persistence of clinical symptoms after mild traumatic brain injury, a multi-scanner study.Frontiers in neuroimaging · 2023Article
- Altered longitudinal structural connectome in paediatric mild traumatic brain injury: an Advancing Concussion Assessment in Paediatrics study.Brain communications · 2023Article
- Differential Patterns of Change in Brain Connectivity Resulting from Severe Traumatic Brain Injury.Brain connectivity · 2022Article
- Effects of White-Matter Tract Length in Sport-Related Concussion: A Tractography Study from the NCAA-DoD CARE Consortium.Journal of neurotrauma · 2022Article
- Connectomic assessment of injury burden and longitudinal structural network alterations in moderate-to-severe traumatic brain injury.Human brain mapping · 2022Article
- Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study.NeuroImage. Clinical · 2021Article
- Compensatory Cross-Modal Plasticity Persists After Sight Restoration.Frontiers in neuroscience · 2020Article
- Evaluation of prolonged administration of isoflurane on cerebral blood flow and default mode network in macaque monkeys anesthetized with different maintenance doses.Neuroscience letters · 2018Article
- Dynamic functional network connectivity discriminates mild traumatic brain injury through machine learning.NeuroImage. Clinical · 2018Article
- Applications of Resting State Functional MR Imaging to Traumatic Brain Injury.Neuroimaging clinics of North America · 2017Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Mild traumatic brain injury (mTBI) accounts for over one million emergency visits each year in the United States. The large-scale structural and functional network connectivity changes of mTBI are still unknown. This study was designed to determine the connectome-scale brain network connectivity changes in mTBI at both structural and functional levels. 40 mTBI patients at the acute stage and 50 healthy controls were recruited. A novel approach called Dense Individualized and Common Connectivity-based Cortical Landmarks (DICCCOLs) was applied for connectome-scale analysis of both diffusion tensor imaging and resting state functional MRI data. Among 358 networks identified on DICCCOL analysis, 41 networks were identified as structurally discrepant between patient and control groups. The involved major white matter tracts include the corpus callosum, and superior and inferior longitudinal fasciculi. Functional connectivity analysis identified 60 connectomic signatures that differentiate patients from controls with 93.75% sensitivity and 100% specificity. Analysis of functional domains showed decreased intra-network connectivity within the emotion network and among emotion-cognition interactions, and increased interactions among action-emotion and action-cognition as well as within perception networks. This work suggests that mTBI may result in changes of structural and functional connectivity on a connectome scale at the acute stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.