Evidence map›Paper›PMID 27408785›Full record

ArticleRespiratory medicine case reports2016

Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up.

Jason Weatherald, Johan Lategan, Doug Helmersen

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Severe Pulmonary Hypertension Due to Adult-Onset Still's Disease.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jason WeatheraldDivision of Respirology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Johan LateganDivision of Hematology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Doug HelmersenDivision of Respirology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult onset Still's disease (AOSD) is an autoimmune disease characterized by systemic inflammation and is a rarely reported cause of pulmonary arterial hypertension (PAH). We describe the clinical course of a 40-year-old woman who presented with PAH 19 months after a diagnosis of AOSD. Sildenafil and immunosuppressive therapy with cyclosporine resulted in clinical and hemodynamic improvement with long-term survival 15 years after her initial presentation of AOSD. We review the literature for published cases of PAH due to AOSD and discuss the potential mechanisms relating inflammatory diseases and PAH.

Indexed as

6MWD, 6-minute walk distanceAdult onsetANA, antinuclear antibodyAOSD, adult onset Still’s diseaseCyclosporineIL, interleukinmPAP, mean pulmonary arterial pressureNFAT, nuclear factor of activated T cellsPAH, pulmonary arterial hypertensionPH, pulmonary hypertensionPulmonary arterial hypertensionPVR, pulmonary vascular resistanceRF, rheumatoid factorRHC, right heart catheterizationRVSP, right ventricular systolic pressureSildenafilSLE, systemic lupus erythematosusStill’s diseaseWHO, World Health Organization

Identifiers

PMID27408785
PMCPMC4927635
OpenAlexW2465299204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.