ArticleGut pathogens2016
Comparative genomic analysis of Klebsiella pneumoniae subsp. pneumoniae KP617 and PittNDM01, NUHL24835, and ATCC BAA-2146 reveals unique evolutionary history of this strain.
Article in Gut pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 40 citations in OpenAlex.
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- Characterization and genome analysis of the Klebsiella webervirus vB_KpnS_2146-302.Archives of virology · 2025Article
- Complete genome sequence, phenotypic correlation and pangenome analysis of uropathogenic Klebsiella spp.AMB Express · 2024Article
- Clinical and Genomic Characterization of Carbapenem-ResistantMicroorganisms · 2023Article
- Characterization and Diversity ofInternational journal of molecular sciences · 2023Article
- Characterization of hydrocarbon degrading microorganisms from Glycine max and Zea mays phytoremediated crude oil contaminated soil.Environmental analysis, health and toxicology · 2022Article
- Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous)Antibiotics (Basel, Switzerland) · 2022Article
- Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced byFrontiers in microbiology · 2022Article
- Genomic Analysis of Prophages fromMicroorganisms · 2021Article
- Soul of the Jukskei River: The Extent of Bacterial Contamination in the Jukskei River in Gauteng Province, South Africa.International journal of environmental research and public health · 2021Article
- Co-introduction of plasmids harbouring the carbapenemase genes, blaJournal of biomedical science · 2020Article
- Prevalence of Klebsiella pneumoniae carbapenemase - and New Delhi metallo-beta-lactamase-positive K. pneumoniae in Sergipe, Brazil, and combination therapy as a potential treatment option.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally CarriedAntimicrobial agents and chemotherapy · 2018Article
- Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.Journal of microbiology (Seoul, Korea) · 2018Article
- Phage Therapy: What Have We Learned?Viruses · 2018Review
- Genomic insights of aromatic hydrocarbon degrading3 Biotech · 2018Article
- A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.Frontiers in microbiology · 2016Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKlebsiella pneumoniae subsp. pneumoniae KP617 is a pathogenic strain that coproduces OXA-232 and NDM-1 carbapenemases. We sequenced the genome of KP617, which was isolated from the wound of a Korean burn patient, and performed a comparative genomic analysis with three additional strains: PittNDM01, NUHL24835 and ATCC BAA-2146.
resultsThe complete genome of KP617 was obtained via multi-platform whole-genome sequencing. Phylogenetic analysis along with whole genome and multi-locus sequence typing of genes of the Klebsiella pneumoniae species showed that KP617 belongs to the WGLW2 group, which includes PittNDM01 and NUHL24835. Comparison of annotated genes showed that KP617 shares 98.3 % of its genes with PittNDM01. Nineteen antibiotic resistance genes were identified in the KP617 genome: bla OXA-1 and bla SHV-28 in the chromosome, bla NDM-1 in plasmid 1, and bla OXA-232 in plasmid 2 conferred resistance to beta-lactams; however, colistin- and tetracycline-resistance genes were not found. We identified 117 virulence factors in the KP617 genome, and discovered that the genes encoding these factors were also harbored by the reference strains; eight genes were lipopolysaccharide-related and four were capsular polysaccharide-related. A comparative analysis of phage-associated regions indicated that two phage regions are specific to the KP617 genome and that prophages did not act as a vehicle for transfer of antimicrobial resistance genes in this strain.
conclusionsWhole-genome sequencing and bioinformatics analysis revealed similarity in the genome sequences and content, and differences in phage-related genes, plasmids and antimicrobial resistance genes between KP617 and the references. In order to elucidate the precise role of these factors in the pathogenicity of KP617, further studies are required.
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