ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2016
Chronic Myeloid Leukemia Developing After Successful Treatment of Acute Promyelocytic Leukemia.
Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Therapy-Related Pure Erythroid Leukaemia with Complex Karyotype Following Successful Treatment for Acute Promyelocytic Leukaemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Chronic myeloid leukemia developing in treated acute promyelocytic leukemia.Hematology, transfusion and cell therapyArticle
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4 authors at 1 institution in 1 country.
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Abstract
Acute promyelocytic leukemia (APL) has been regarded as a highly curable disease. Therapy-related leukemia is one of the important late complications that affect long-term survival rates in APL patients. Therapy-related acute myeloid leukemia and myelodysplastic syndrome are the major forms of therapy-related leukemias. We report a rare event of chronic myeloid leukemia (CML) that developed after successful treatment of APL with all-trans-retinoic acid in combination with chemotherapy. Rather unexpectedly, CML developed 7 years after APL. Cytogenetic and molecular studies proved the independence of these two entities. It was found that CML progressed rapidly after a short-term response to a combination therapy with hydroxyurea, interferon-α and arsenic trioxide. We propose that optimization of chemotherapy regimen and treatment intensity may reduce the risk of developing a secondary leukemia, while long-term monitoring cytogenetics of APL patients after treatment may help determine the development of a secondary leukemia at early stage.
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