Evidence map›Paper›PMID 27408333›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2016

Effects of the -791(C→T) mutation in the promoter for tumor necrosis factor alpha on gene expression and resistance of Large White pigs to enterotoxigenic Escherichia coli F18.

Ying Liu, Chaohui Dai, Li Sun, Guoqiang Zhu, Shenglong Wu, Wenbin Bao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying LiuDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Chaohui DaiDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Li SunDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Guoqiang ZhuDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Shenglong WuDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Wenbin BaoDepartment of College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Liu, Dai, Sun, Wu, Bao); Department of College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China (Zhu).
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor alpha (TNF-α) plays an important role in the immune system. In this study, TNF-α expression was analyzed in 11 tissues of 8 piglets resistant to enterotoxigenic Escherichia coli (ETEC) F18 and 8 ETEC F18-susceptible piglets from the Large White breed. The expression levels of TNF-α were high in immune organs (spleen, lung, thymus, and lymph nodes). The levels were higher in ETEC F18-resistant piglets than in ETEC F18-susceptible piglets, with significant differences in spleen, kidney, thymus, lymph node, and duodenum (P < 0.05). The mutation TNF-α -791(C→T) and 3 genotypes (CC, CT, and TT) were identified. The TNF-α expression levels in the spleen, kidney, lymph nodes, and duodenum were significantly higher in the TT pigs than in the CC pigs (P < 0.05). Thus, TNF-α -791(C→T) has significant effects on mRNA expression and may regulate ETEC F18 resistance of weaning piglets. Therefore, the -791(C→T) mutation of the TNF-α gene could be considered an important potential genetic marker of ETEC F18 resistance.

Indexed as

Genetic Predisposition to DiseaseAnimalsEnterotoxigenic Escherichia coliEscherichia coli InfectionsGene Expression RegulationGenetic MarkersPromoter Regions, GeneticRNA, MessengerSwineSwine DiseasesTissue DistributionTumor Necrosis Factor-alphaGenetic MarkersRNA, MessengerTumor Necrosis Factor-alpha

Identifiers

PMID27408333
PMCPMC4924554
OpenAlexW2484579714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.