ArticleIndian journal of microbiology2016
Role of Indole Production on Virulence of Vibrio cholerae Using Galleria mellonella Larvae Model.
Article in Indian journal of microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Structure and dynamics of Proteus vulgaris tryptophan indole-lyase complexes with l-ethionine and l-alanine.Archives of biochemistry and biophysics · 2025Article
- Advances in cholera research: from molecular biology to public health initiatives.Frontiers in microbiology · 2023Review
- Review
- Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms.Microorganisms · 2021Article
- Dietary Isothiocyanates, Sulforaphane and 2-Phenethyl Isothiocyanate, Effectively ImpairInternational journal of molecular sciences · 2021Article
- Genotypic Diversity and Pathogenic Potential of Clinical and EnvironmentalFrontiers in microbiology · 2021Article
- Indole and Derivatives Modulate Biofilm Formation and Antibiotic Tolerance ofIndian journal of microbiology · 2019Article
- Indole Inhibits ToxR Regulon Expression inInfection and immunity · 2019Article
- Aryl hydrocarbon receptor and intestinal immunity.Mucosal immunology · 2018Review
- Vibrio cholerae accessory colonisation factor AcfC: a chemotactic protein with a role in hyperinfectivity.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell to cell communication facilitated by chemical signals plays crucial roles in regulating various cellular functions in bacteria. Indole, one such signaling molecule has been demonstrated to control various bacterial phenotypes such as biofilm formation and virulence in diverse bacteria including Vibrio cholerae. The present study explores some key factors involved in indole production and the subsequent pathogenesis of V. cholerae. Indole production was higher at 37 °C than at 30 °C, although the growth at 37 °C was slightly higher. A positive correlation was observed between indole production and biofilm formation in V. cholerae. Maximum indole production was detected at pH 7. There was no significant difference in indole production between clinical and environmental V. cholerae isolates, although indole production in one environmental isolate was significantly different. Both growth and indole production showed relevant changes with differences in salinity. An indole negative mutant strain was constructed using transposon mutagenesis and the direct effect of indole on the virulence of V. cholerae was evaluated using Galleria mellonella larvae model. Comparison to the wild type strain, the mutant significantly reduced the mortality of G. mellonella larvae which regained its virulence after complementation with exogenous indole. A gene involved in indole production and the virulence of V. cholerae was identified.
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