Evidence map›Paper›PMID 27407238›Full record

ArticleReumatologia2015

Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis.

Zbigniew Żuber, Dorota Turowska-Heydel, Małgorzata Sobczyk, Jerzy Chudek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reumatologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Recent updates in enthesitis-related arthritis.Rheumatology international · 2023
    Review
  13. Article
  14. New Insights on Juvenile Psoriatic Arthritis.Frontiers in pediatrics · 2022
    Review
  15. Article
  16. Juvenile Spondyloarthritis: focus on uveitis.Pediatric rheumatology online journal · 2020
    Article
  17. Enthesitis-related arthritis: current perspectives.Open access rheumatology : research and reviews · 2019
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zbigniew ŻuberDepartment of Older Children with Subwards of Rheumatology, Neurology and Rehabilitation, St. Louis Children's Hospital, Krakow, Poland.
Dorota Turowska-HeydelDepartment of Older Children with Subwards of Rheumatology, Neurology and Rehabilitation, St. Louis Children's Hospital, Krakow, Poland.
Małgorzata SobczykDepartment of Older Children with Subwards of Rheumatology, Neurology and Rehabilitation, St. Louis Children's Hospital, Krakow, Poland.
Jerzy ChudekChair of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
Uniwersytecki Szpital Dziecięcy · PLMedical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA). The aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on disease onset and response to conventional therapy. MATERIAL AND

methodsThe retrospective analysis included 461 unselected children with JIA hospitalized in a single reference rheumatology centre between July 2007 and June 2012. The diagnosis was based on criteria by the International League of Association for Rheumatology. HLA-B27 was determined in 387 of all patients (84%) by hybridization of the amplified, labelled product to immobilize it on the microarray probe.

resultsHLA-B27 antigen was found in 104 of 383 affected children (27.2%), 48 of 206 girls (23.3%), and 56 of 177 boys (31.6%) - most frequently in patients with enthesitis-related arthritis (71%), psoriatic arthritis (50%) and unclassified cases (86.7%). The age of JIA onset was slightly (by 1 year) but significantly different in patients with and without HLA-B27 antigen [11 (8.5-14) vs. 10 (5-13.5) years.; p < 0.001]. The use of disease-modifying antirheumatic drugs (DMARDs) and corticosteroids was more frequently clinically ineffective in HLA-B27 positive than negative patients (23.1% vs. 15.2%; p = 0.09). Patients with polyarthritis, systemic, and psoriatic arthritis more frequently received biological therapy. HLA-B27 positive patients with enthesitis-related arthritis received biological therapy more frequently than HLA-B27 negative ones (20.4% vs. 0, respectively; p = 0.09).

conclusionsHLA-B27 antigen is a strong risk factor for the development of enthesitis-related arthritis, and to a lesser extent for psoriatic arthritis and extended course of oligoarthritis. The presence of this antigen does not affect the disease onset but seems to predict resistance to therapy with disease-modifying drugs and corticosteroids.

Indexed as

HLA-B27 antigenjuvenile idiopathic arthritistherapy

Identifiers

PMID27407238
PMCPMC4847302
OpenAlexW2489532171

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.