ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2016
A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into the regulation of stilbene accumulation.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Grape Berry Secondary Metabolites and Their Modulation by Abiotic Factors in a Climate Change Scenario-A Review.Frontiers in plant science · 2021Pooled it
- Network aggregation improves gene function prediction of grapevine gene co-expression networks.Plant molecular biology · 2020Pooled it
- Dissecting gene regulatory networks driving grape berry ripening using comparative systems biology across nonclimacteric fleshy fruits: the NAC-centered hierarchy revisited.Horticulture research · 2026Review
- Article
- A voyage of reprogrammable metabolic bioengineering reshapes plant defense: from editing tools to synthetic systems.Frontiers in plant science · 2026Review
- VqERF1B-VqERF062-VqNSTS2 transcriptional cascade enhances stilbene biosynthesis and resistance to powdery mildew in grapevine.Plant biotechnology journal · 2025Article
- Pan-genome analysis of the R2R3-MYB genes family inFrontiers in plant science · 2025Article
- NAC61 regulates late- and post-ripening osmotic, oxidative, and biotic stress responses in grapevine.Journal of experimental botany · 2024Article
- Exploring large-scale gene coexpression networks in peach (Horticulture research · 2024Article
- Overexpression of a 'Beta' MYB Factor Gene,International journal of molecular sciences · 2024Article
- MYB24 orchestrates terpene and flavonol metabolism as light responses to anthocyanin depletion in variegated grape berries.The Plant cell · 2023Article
- The flavour of grape colour: anthocyanin content tunes aroma precursor composition by altering the berry microenvironment.Journal of experimental botany · 2023Article
- Transcriptomic Analysis Reveals Novel Regulators of the Scots Pine Stilbene Pathway.Plant & cell physiology · 2023Article
- Genomic-wide identification and expression analysis of R2R3-MYB transcription factors related to flavonol biosynthesis in Morinda officinalis.BMC plant biology · 2023Article
- Function of the R2R3-MYB Transcription Factors inInternational journal of molecular sciences · 2023Article
- Overexpression of a Grape MYB Transcription Factor GeneInternational journal of molecular sciences · 2023Article
- Identification of Vitis vinifera MYB transcription factors and their response against grapevine berry inner necrosis virus.BMC plant biology · 2023Article
- Dissecting the effect of soil on plant phenology and berry transcriptional plasticity in two Italian grapevine varieties (Horticulture research · 2023Article
- Identification and Phylogenetic Analysis of thePlants (Basel, Switzerland) · 2023Article
- MYB30 and MYB14 form a repressor-activator module with WRKY8 that controls stilbene biosynthesis in grapevine.The Plant cell · 2023Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
R2R3-MYB transcription factors (TFs) belong to a large and functionally diverse protein superfamily in plants. In this study, we explore the evolution and function of this family in grapevine (Vitis vinifera L.), a high-value fruit crop. We identified and manually curated 134 genes using RNA-Seq data, and named them systematically according to the Super-Nomenclature Committee. We identified novel genes, splicing variants and grapevine/woody-specific duplicated subgroups, suggesting possible neo- and sub-functionalization events. Regulatory network analysis ascribed biological functions to uncharacterized genes and validated those of known genes (e.g. secondary cell wall biogenesis and flavonoid biosynthesis). A comprehensive analysis of different MYB binding motifs in the promoters of co-expressed genes predicted grape R2R3-MYB binding preferences and supported evidence for putative downstream targets. Enrichment of cis-regulatory motifs for diverse TFs reinforced the notion of transcriptional coordination and interaction between MYBs and other regulators. Analysis of the network of Subgroup 2 showed that the resveratrol-related VviMYB14 and VviMYB15 share common co-expressed STILBENE SYNTHASE genes with the uncharacterized VviMYB13. These regulators have distinct expression patterns within organs and in response to biotic and abiotic stresses, suggesting a pivotal role of VviMYB13 in regulating stilbene accumulation in vegetative tissues and under biotic stress conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.