ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
Trajectories of Stress, Depressive Symptoms, and Immunity in Cancer Survivors: Diagnosis to 5 Years.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Approach to stress endocrine response: somatization in the context of gastroenterological symptoms: a systematic review.African health sciences · 2019Pooled it
- Lemons to lemonade: Effects of a biobehavioral intervention for cancer patients on later life changes.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Trial
- Hope and benefit finding: Results from the PRISM randomized controlled trial.Pediatric blood & cancer · 2019Trial
- Evaluating the effectiveness and implementation of evidence-based treatment: A multisite hybrid design.The American psychologistTrial
- Temporal Trends in Cause-Specific Cardiovascular Disease Mortality Following Cancer Diagnosis.Cancer medicine · 2026Article
- Negative automatic thoughts mediate the effects of emotion regulation on distress in women with breast and gynecological cancer.Scientific reports · 2026Article
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- Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Unsupervised machine learning reveals prognostic value of dynamic carbohydrate antigen 125 trajectory in gastric cancer.BMC cancer · 2025Article
- Insomnia Proven to be Associated With Prostate Cancer: A Genetic Correlation Study Incorporating Lifestyle Factors.Alpha psychiatry · 2025Article
- The mediating role of resilience in the relationships between posttraumatic growth and depression as well as anxiety among survivors of nasopharyngeal carcinoma: a cross-sectional study.BMC psychology · 2025Article
- Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning.Discover oncology · 2025Article
- Lung cancer patients' illness perceptions: Prognostic for psychological and physical health trajectories.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- The role of illness-related cognition in the relationships between resilience and depression/anxiety in nasopharyngeal cancer patients.Cancer medicine · 2023Article
- Circulating biomarkers in perioperative management of cancer patients.Precision clinical medicine · 2023Review
- Trajectories of cancer-specific stress in cancer patients: a latent growth mixture analysis.Journal of behavioral medicine · 2023Article
- Sleep reactivity predicts insomnia in patients diagnosed with breast cancer.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Anxiety and depression among Black breast cancer survivors: Examining the role of patient-provider communication and cultural values.Patient education and counseling · 2022Article
- Illness perception profiles and psychological and physical symptoms in newly diagnosed advanced non-small cell lung cancer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Visual cues of the built environment and perceived stress among a cohort of black breast cancer survivors.Health & place · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeFive-year disease endpoint trajectories are available for every cancer site. In contrast, there are few longitudinal, biobehavioral studies of survivors extending beyond the first or second year following diagnosis. This gap is addressed with stress, depressive symptom, and immunity data from breast cancer patients followed continuously for 5 years. EXPERIMENTAL
designWomen (N = 113) diagnosed and surgically treated for breast cancer and awaiting adjuvant therapy completed self-report measures of stress and depressive symptoms and provided blood for immune assays [natural killer cell cytotoxicity (NKCC) and T-cell blastogenesis]. Assessments (N = 12) were repeated every 4 to 6 months for 5 years.
resultsMultiphase linear mixed models show phases of change and identified specific time points of change. Cancer stress shows two distinct phases of decline, with the change point being 12 months. In contrast, a steep decline in depressive symptoms occurs by 7 months, with stable, low levels thereafter. NKCC shows a steady upward trajectory through 18 months and upper limit stability thereafter, whereas there was no reliable trajectory for T-cell blastogenesis.
conclusionsFor the first time, trajectories and specific time points of change in biobehavioral data for breast cancer survivors are provided, traced through 5 years. Following diagnosis, the breast survivor experience is one of a co-occurrence of change (recovery) in psychologic and innate immunity markers from diagnosis to18 months, and a pattern of stability (depression, NKCC) or continued improvement (stress) through year 5. These data provide new directions for survivorship care and detail of the biobehavioral trajectory. Clin Cancer Res; 23(1); 52-61. ©2016 AACR.
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