Evidence map›Paper›PMID 27407071›Full record

ArticleCirculation2016

Long-Term Outcomes From Acute Rheumatic Fever and Rheumatic Heart Disease: A Data-Linkage and Survival Analysis Approach.

Vincent Y F He, John R Condon, Anna P Ralph, Yuejen Zhao, Kathryn Roberts, Jessica L de Dassel, Bart J Currie, Marea Fittock, Keith N Edwards, Jonathan R Carapetis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Vincent Y F HeFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
John R CondonFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Anna P RalphFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.). Anna.Ralph@menzies.edu.au.
Yuejen ZhaoFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Kathryn RobertsFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Jessica L de DasselFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Bart J CurrieFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Marea FittockFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Keith N EdwardsFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Jonathan R CarapetisFrom Menzies School of Health Research, Charles Darwin University, Darwin, Australia (V.Y.F.H., J.R.C., A.P.R., K.R., J.L.d.D., B.J.C.); Royal Darwin Hospital (A.P.R., K.R., B.J.C., K.N.E.) and Health Gains Planning Branch (Y.Z.), Northern Territory Government Department of Health, Darwin, Australia; Northern Territory Rheumatic Heart Disease Control Program, Centre for Disease Control, NT Department of Health, Darwin, Australia (M.F., K.N.E.); Telethon Kids Institute, University of Western Australia, Perth, Australia (J.R.C.); and Princess Margaret Hospital for Children, Perth, Australia (J.R.C.).
Charles Darwin University · AUGovernment of Western Australia Department of Health · AUMenzies School of Health Research · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated adverse outcomes for people with acute rheumatic fever (ARF) and rheumatic heart disease (RHD) and the effect of comorbidities and demographic factors on these outcomes.

methodsUsing linked data (RHD register, hospital, and mortality data) for residents of the Northern Territory of Australia, we calculated ARF recurrence rates, rates of progression from ARF to RHD to severe RHD, RHD complication rates (heart failure, endocarditis, stroke, and atrial fibrillation), and mortality rates for 572 individuals diagnosed with ARF and 1248 with RHD in 1997 to 2013 (94.9% Indigenous).

resultsARF recurrence was highest (incidence, 3.7 per 100 person-years) in the first year after the initial ARF episode, but low-level risk persisted for >10 years. Progression to RHD was also highest (incidence, 35.9) in the first year, almost 10 times higher than ARF recurrence. The median age at RHD diagnosis in Indigenous people was young, especially among males (17 years). The development of complications was highest in the first year after RHD diagnosis: heart failure incidence rate per 100 person-years, 9.09; atrial fibrillation, 4.70; endocarditis, 1.00; and stroke, 0.58. Mortality was higher among Indigenous than non-Indigenous RHD patients (hazard ratio, 6.55; 95% confidence interval, 2.45-17.51), of which 28% was explained by comorbid renal failure and hazardous alcohol use. RHD complications and mortality rates were higher for urban than for remote residents.

conclusionsThis study provides important new prognostic information for ARF/RHD. The residual Indigenous survival disparity in RHD patients, which persisted after accounting for comorbidities, suggests that other factors contribute to mortality, warranting further research.

Indexed as

Acute DiseaseAdolescentAdultAgedAlcoholismAtrial FibrillationChildChild, PreschoolComorbidityDisease ProgressionEndocarditisFemaleFollow-Up StudiesHeart FailureHospitalizationHumansalcohol drinkingcomorbiditycomplicationsheart failurerheumatic heart diseasesurvival analysis

Identifiers

PMID27407071
PMCPMC4949009
OpenAlexW2475518574

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.