ArticleJournal of biomedical materials research. Part B, Applied biomaterials2017
Silk fibroin scaffolds with inverse opal structure for bone tissue engineering.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- In Vitro Investigation of 3D Printed Hydrogel Scaffolds with Electrospun Tidemark Component for Modeling Osteochondral Interface.Gels (Basel, Switzerland) · 2024Article
- Impact of Hydroxyapatite on Gelatin/Oxidized Alginate 3D-Printed Cryogel Scaffolds.Gels (Basel, Switzerland) · 2024Article
- Silk fibroin carriers with sustained release capacity for treating neurological diseases.Frontiers in pharmacology · 2023Review
- Augmenting Tendon-to-Bone Repair with Functionally Graded Scaffolds.Advanced healthcare materials · 2021Review
- Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors.Communications biology · 2021Article
- Spatial alignment of 3D printed scaffolds modulates genotypic expression in pre-osteoblasts.Materials letters · 2020Article
- Orbital seeding of mesenchymal stromal cells increases osteogenic differentiation and bone-like tissue formation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Protein-Based Fiber Materials in Medicine: A Review.Nanomaterials (Basel, Switzerland) · 2018Review
- Article
- Inverse opal substrate-loaded mesenchymal stem cells contribute to decreased myocardial remodeling after transplantation into acute myocardial infarction mice.International journal of nanomedicine · 2018Article
- Silk fibroin scaffolds with inverse opal structure for bone tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017Review
- Evaluation of Silk Inverse Opals for "Smart" Tissue Culture.ACS omega · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How scaffold porosity, pore diameter and geometry influence cellular behavior is-although heavily researched - merely understood, especially in 3D. This is mainly caused by a lack of suitable, reproducible scaffold fabrication methods, with processes such as gas foaming, lyophilization or particulate leaching still being the standard. Here we propose a method to generate highly porous silk fibroin scaffolds with monodisperse spherical pores, namely inverse opals, and study their effect on cell behavior. These silk fibroin inverse opal scaffolds were compared to salt-leached silk fibroin scaffolds in terms of human mesenchymal stem cell response upon osteogenic differentiation signals. While cell number remained similar on both scaffold types, extracellular matrix mineralization nearly doubled on the newly developed scaffolds, suggesting a positive effect on cell differentiation. By using the very same material with comparable average pore diameters, this increase in mineral content can be attributed to either the differences in pore diameter distribution or the pore geometry. Although the exact mechanisms leading to enhanced mineralization in inverse opals are not yet fully understood, our results indicate that control over pore geometry alone can have a major impact on the bioactivity of a scaffold toward stem cell differentiation into bone tissue. © 2016 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2074-2084, 2017.
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