Evidence map›Paper›PMID 27406995›Full record

ReviewJournal of leukocyte biology2016

Angiogenesis and wound repair: when enough is enough.

Luisa A DiPietro

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of leukocyte biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Luisa A DiPietroCenter for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois.

Funding

ANGIOGENESIS IN WOUND REPAIRR01GM050875 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIPIETRO, LUISA A · 1999 to 2020
$6.6M
MicroRNA regulation of the injury response in oral mucosaR21DE025926 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIPIETRO, LUISA A, ZHOU, XIAOFENG · 2016 to 2017
$440k
NIDCR NIH HHS R21 DE025926NIGMS NIH HHS R01 GM050875
6 · The paper itself

Abstract

All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes.

Indexed as

Angiogenic ProteinsAnimalsCapillariesCicatrixEndothelial CellsFetusFibrosisHumansInflammationMouth MucosaNeovascularization, PhysiologicPericytesPrenatal InjuriesRegenerationSkinWound HealingAngiogenic ProteinscapillaryfibrosisinflammationscarVEGFwound healing

Identifiers

PMID27406995
PMCPMC6608066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.