Evidence map›Paper›PMID 27406921›Full record

ArticleBiology of the cell2016

Aquaglyceroporin function in the malaria mosquito Anopheles gambiae.

Kun Liu, Hitoshi Tsujimoto, Yuzheng Huang, Jason L Rasgon, Peter Agre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evolutionary Overview of Aquaporin Superfamily.Advances in experimental medicine and biology · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Biology, Bionomics and Molecular Biology ofFrontiers in microbiology · 2017
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Kun LiuDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, MD, 21205, USA.
Hitoshi TsujimotoDepartment of Entomology, The Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Yuzheng HuangJiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu 214064, China.
Jason L RasgonDepartment of Entomology, The Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. JLR54@psu.edu.
Peter AgreDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, MD, 21205, USA.
Center for Disease Dynamics, Economics & Policy · USJiangsu Provincial Academy of Traditional Chinese Medicine · CNJohns Hopkins University · USNew Mexico State University · USPacific Northwest National Laboratory · US

Funding

TransmissionU19AI089680 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM J MOSS · 2010 to 2026
$25.6M
STUDIES OF RED CELL 28 KDA PROTEINR01HL048268 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AGRE, PETER C · 1992 to 2011
$2.0M
Genetic basis of WNV vector competence in Culex tarsalisR01AI067371 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2007 to 2011
$2.0M
Wolbachia-induced enhancement of human arboviral pathogensR01AI116636 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2016 to 2020
$1.9M
Efficient site-specific genetic engineering of the Anopheles gambiae genomeR21AI088311 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2010 to 2011
$439k
ReMOT Control of mosquito transgenesisR21AI111175 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2014 to 2015
$411k
NHLBI NIH HHS R01 HL048268NIAID NIH HHS R01 AI067371NIAID NIH HHS R01 AI116636NIAID NIH HHS R21 AI088311NIAID NIH HHS R21 AI111175NIAID NIH HHS U19 AI089680
6 · The paper itself

Abstract

background informationAnopheles gambiae is the major mosquito vector for Plasmodium falciparum malaria in sub-Saharan Africa, where it survives in stressful climates. Aquaporin water channels are expressed in all life forms, where they provide environmental adaptation by conferring rapid trans-cellular movement of water (classical aquaporins) or water plus glycerol (aquaglyceroporins). Here, we report an aquaglyceroporin homolog in A. gambiae, AgAQP3 (A. gambiae aquaglyceroporin 3).

resultsDespite atypical pore-lining amino acids, AgAQP3 is permeated by water, glycerol and urea, and is not significantly inhibited by 1 mM HgCl

conclusionsOur studies reveal critical contributions of AgAQP3 to A. gambiae heat tolerance and P. falciparum development in vivo. SIGNIFICANCE: This study indicates that AgAQP3 may be a major factor explaining why A. gambiae is an important malaria vector mosquito in sub-Saharan Africa, and may be a potential target for novel malaria control strategies.

Indexed as

Adaptation, PhysiologicalAnimalsAnophelesAquaporin 3FemaleHot TemperatureHumansInsect ProteinsInsect VectorsMalaria, FalciparumMalePlasmodium falciparumRNA InterferenceRNA, Small InterferingStress, PhysiologicalAquaporin 3Insect ProteinsRNA, Small InterferingAnopheles gambiaeAquaglyceroporinGene silencingMalaria controlStress adaptation

Identifiers

PMID27406921
PMCPMC5731640
OpenAlexW2470589943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.