Observational studyCirculation. Cardiovascular imaging2016
Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy: A Multimodality Study.
Observational study in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Survival and Cardiovascular Outcomes of Patients With Secondary Mitral Regurgitation: A Systematic Review and Meta-analysis.JAMA cardiology · 2017Pooled it
- Identifying Responders to Transcatheter Interventions for Secondary Mitral Regurgitation.Current treatment options in cardiovascular medicine · 2025Review
- Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis.European heart journal. Imaging methods and practice · 2025Article
- Prognosis and predictors of right ventricular dysfunction by quantitative cardiac magnetic resonance in non-ischaemic cardiomyopathy.European heart journal. Cardiovascular Imaging · 2024Article
- Cardiac MRI-Enriched Phenomapping Classification and Differential Treatment Outcomes in Patients With Ischemic Cardiomyopathy.Circulation. Cardiovascular imaging · 2024Article
- The Role of Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral Regurgitation.Diagnostics (Basel, Switzerland) · 2024Review
- Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy.JACC. Advances · 2024Article
- Perspectives on Secondary Mitral Regurgitation in Heart Failure.Current heart failure reports · 2023Review
- Wall Motion Score Index Predicts Persistent Moderate or Severe Secondary Mitral Regurgitation and its Prognostic Role in Patients Undergoing Percutaneous Coronary Intervention.Reviews in cardiovascular medicine · 2023Article
- The Role of Cardiovascular Magnetic Resonance in Patients with Mitral Regurgitation.Journal of cardiovascular development and disease · 2022Review
- Review: application of current imaging modalities in the management of left-sided valvular heart disease.Cardiovascular diagnosis and therapy · 2021Review
- Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.JACC. Cardiovascular imaging · 2021Article
- Secondary mitral regurgitation-Insights from microRNA assessment.European journal of clinical investigation · 2021Article
- Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction.European heart journal · 2020Review
- Assessment of mitral valve regurgitation by cardiovascular magnetic resonance imaging.Nature reviews. Cardiology · 2020Review
- Advances in MRI Applications to Diagnose and Manage Cardiomyopathies.Current treatment options in cardiovascular medicine · 2019Review
- Evolution of secondary mitral regurgitation.European heart journal. Cardiovascular Imaging · 2018Article
- Multimodality imaging assessment of mitral valve anatomy in planning for mitral valve repair in secondary mitral regurgitation.Journal of thoracic disease · 2017Review
- Anticipating the Vicious Circle of Postinfarction Mitral Regurgitation: Imaging Insights.Circulation. Cardiovascular imaging · 2016Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic mitral regurgitation (IMR) is associated with poor outcomes. It is unknown what factors contribute to progression of IMR and how progressive IMR affects outcomes. We sought to determine imaging predictors of IMR progression and to determine if progressive IMR is an independent predictor of survival in patients with advanced ischemic cardiomyopathy. METHODS AND
resultsConsecutive advanced ischemic cardiomyopathy patients who underwent cardiac magnetic resonance and echocardiograms at baseline with echocardiographic follow-up were studied. Cardiac magnetic resonance was used to assess left ventricular volumes, infarct size, and mitral valve geometry. The effective regurgitant orifice area (EROA) was calculated from the proximal isovelocity surface area by echocardiography. Repeated measures mixed effects and Cox proportional hazards regression models were built to identify predictors of IMR progression and survival. We evaluated 336 patients (age, 62±11 years) over a median follow-up time of 54 months: 154 patients were subsequently revascularized, and 182 patients were medically treated. Ninety-eight patients (29%) demonstrated an increase in EROA values of ≥0.1 cm(2). There were 87 adverse events (death or transplant). On multivariable analysis, infarct size (P<0.001), progression in IMR (P=0.008), age (P=0.003), and baseline EROA (P=0.010) were independently associated with adverse events. Independent predictors of IMR progression were as follows: baseline EROA (P<0.001), left ventricular end-systolic volume index (P=0.014), and total scar (P=0.036).
conclusionsIMR frequently increases in severity, and progression is independently associated with adverse left ventricular remodeling and infarct size, as assessed by cardiac magnetic resonance. Furthermore, IMR progression is a powerful independent predictor of adverse events, even after controlling for the severity of IMR at baseline.
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