ArticleScientific reports2016
Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall.Scientific reports · 2021Article
- Intelligent magnetic manipulation for gastrointestinal ultrasound.Science robotics · 2019Article
- Ingestible Electronics for Diagnostics and Therapy.Nature reviews. Materials · 2019Article
- Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.Journal of cell science · 2017Article
- Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy.Sensors (Basel, Switzerland) · 2017Article
- Ultrasound capsule endoscopy: sounding out the future.Annals of translational medicine · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic.
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Registered trials
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