ArticleNeurocritical care2016
EEG Characteristics of Successful Burst Suppression for Refractory Status Epilepticus.
Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Does status epilepticus in pediatric patients severity score (STEPSS) predict functional outcomes in children admitted to PICU? A retrospective single-center study.BMC pediatrics · 2026Article
- Guidance for: The acute management of status epilepticus in adult patients.Journal of the Intensive Care Society · 2025Article
- Utility and rationale for continuous EEG monitoring: a primer for the general intensivist.Critical care (London, England) · 2024Review
- Status epilepticus in the ICU.Intensive care medicine · 2024Review
- Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Processed Electroencephalogram-Based Monitoring to Guide Sedation in Critically Ill Adult Patients: Recommendations from an International Expert Panel-Based Consensus.Neurocritical care · 2023Article
- Severity scores for status epilepticus in the ICU: systemic illness also matters.Critical care (London, England) · 2023Observational
- Diversity of electroencephalographic patterns during propofol-induced burst suppression.Frontiers in systems neuroscience · 2023Article
- Recent applications of quantitative electroencephalography in adult intensive care units: a comprehensive review.Journal of neurology · 2022Review
- Does electroencephalographic burst suppression still play a role in the perioperative setting?Best practice & research. Clinical anaesthesiology · 2021Review
- Seizure Management in the Intensive Care Unit.Current treatment options in neurology · 2021Review
- Quantitative burst suppression on serial intermittent EEG in refractory status epilepticus.Clinical neurophysiology practice · 2021Article
- Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus.Brain : a journal of neurology · 2020Article
- Observational
- Successful Wean Despite Emergence of Ictal-Interictal EEG Patterns During the Weaning of Prolonged Burst-Suppression Therapy for Super-Refractory Status Epilepticus.Neurocritical care · 2018Article
- Does burst-suppression achieve seizure control in refractory status epilepticus?BMC neurology · 2018Article
- Updates in Refractory Status Epilepticus.Critical care research and practice · 2018Review
- Periodic Lateralized Epileptiform Discharges can Survive Anesthesia and Result in Asymmetric Drug-induced Burst Suppression.Neurology international · 2017Article
- Flat Out Unnecessary: Burst Characteristics, Not Duration of Interburst Intervals, Predict Successful Anesthetic Wean in Refractory Status Epilepticus.Epilepsy currentsArticle
- To Wean or Not to Wean: Machine Learning to the Rescue.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRefractory status epilepticus (RSE) is often treated with continuous intravenous medications with the goal of EEG burst suppression. Standard advice is to titrate medications to at least 10-s interburst intervals; however, this has not been shown to improve outcome. We examined EEG characteristics in patients treated with IV anesthetic therapy (IVAT) for RSE to determine which EEG characteristics were associated with successful lifting of IVAT (i.e., without recurrence of status epilepticus).
methodsWe screened the clinical continuous EEG database for adult patients treated with IVAT for RSE (excluding patients with anoxic injury). We measured the length of bursts and interburst intervals for each patient, calculated EEG burst suppression ratios, and graded bursts for the amount of epileptiform activity. We compared these characteristics in successful versus unsuccessful IVAT lifting attempts.
resultsWe included 17 successful and 20 unsuccessful lifting attempts in 19 patients (5 used as a holdout validation set). The interburst intervals, burst suppression ratios, and length of bursts did not differentiate successful and unsuccessful lifting attempts; the amount of epileptiform activity in bursts correlated with success or failure to wean IVAT (p = 0.008). Maximum burst amplitude <125 μV had 84.6 % sensitivity and 61.1 % specificity for predicting successful lifting.
conclusionThe length of interburst intervals and burst suppression did not predict successful termination of RSE in this small cohort. This may suggest that EEG characteristics, rather a strict interburst interval goal, could guide IVAT for RSE.
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