Observational studyJournal of endocrinological investigation2016
Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device.
Observational study in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Treatment Adherence to Injectable Treatments in Pediatric Growth Hormone Deficiency Compared With Injectable Treatments in Other Chronic Pediatric Conditions: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Pooled it
- Multi-centre phase IV trial to investigate the immunogenicity of a new liquid formulation of recombinant human growth hormone in adults with growth hormone deficiency.Journal of endocrinological investigation · 2018Trial
- Pharmacovigilance evaluation of somatrogon-associated adverse events in real-world databases.Endocrine connections · 2026Article
- Yushida: an IoT-based smart injection system for long-term management of chronic diseases.Frontiers in digital health · 2026Review
- The role of digital health in growth hormone therapy: perspectives from Gulf Cooperation Council pediatric endocrinologists.Frontiers in endocrinology · 2025Article
- Interventions Designed to Improve Adherence to Growth Hormone Treatment for Pediatric Patients and Their Families: A Narrative Review.Pharmaceutics · 2022Review
- Patients' Perception of the Use of the EasyPod™ Growth Hormone Injector Device and Impact on Injection Adherence: A Multi-Center Regional Study.Frontiers in pediatrics · 2022Article
- Patient preferences for growth hormone treatment in Japanese children.Pediatrics international : official journal of the Japan Pediatric Society · 2021Article
- Adherence to treatment in children with growth hormone deficiency, small for gestational age and Turner syndrome in Mexico: results of the Easypod™ connect observational study (ECOS).Journal of endocrinological investigation · 2020Observational
- Managing Paediatric Growth Disorders: Integrating Technology Into a Personalised ApproachJournal of clinical research in pediatric endocrinology · 2020Review
- Management of Hypopituitarism.Journal of clinical medicine · 2019Review
- Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS).Journal of endocrinological investigation · 2019Observational
- Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study.Endocrine connections · 2019Article
- Cost-consequence analysis for human recombinant growth hormone (r-hGH) treatment administered via different devices in children with growth hormone deficiency in Italy.ClinicoEconomics and outcomes research : CEOR · 2019Article
- Relevance of Adherence Monitoring in Adult Patients With Growth Hormone Deficiency Under Replacement Therapy: Preliminary Monocentric Data With EasypodFrontiers in endocrinology · 2019Article
- Improvement of treatment adherence with growth hormone by easypod™ device: experience of an Italian centre.Italian journal of pediatrics · 2018Observational
- Adherence and long-term growth outcomes: results from the easypodEndocrine connections · 2018Article
- Long-term response to recombinant human growth hormone treatment: a new predictive mathematical method.Journal of endocrinological investigation · 2018Article
- Optimizing Patient Management and Adherence for Children Receiving Growth Hormone.Frontiers in endocrinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePoor adherence to recombinant human growth hormone (r-hGH) therapy is associated with reduced growth velocity in children with growth hormone deficiency (GHD). This twelve-month observational study was to assess adherence in r-hGH patients treated with the easypod
methodsNinety-seven prepubertal patients receiving r-hGH therapy were included in the study from ten Italian clinical sites and 88 completed the study. To avoid possible confounding effects, only GHD patients (79/88; 89.7 % of the overall study population) were considered in the final analysis. The primary endpoint-adherence to treatment-was calculated as the proportion of injections correctly administered during the observational period out of the expected total number of injections. The relevant information, tracked by the easypod
resultsThe easypod
conclusionsThe injection-recording system and other characteristics of easypod
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.