ArticleHeredity2016
Diet adaptation in dog reflects spread of prehistoric agriculture.
Article in Heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Parallel gene amplification by Cas9 nickase for generating functionally heterogeneous cell populations.Cell reports methods · 2026Article
- Leveraging Dog Models to Uncover Human Cancer Insights.Research square · 2026Article
- Next-Generation Sequencing Insights into the Oral Microbiome and Antibiotic Resistance Genes in Grey Wolves (Animals : an open access journal from MDPI · 2025Article
- Investigation of the Digestibility, Fecal Characteristics, and Palatability of Oil Mil By-Products as a Plant-Based Protein Source in Canine Diets.Animals : an open access journal from MDPI · 2025Article
- Human-Dog Symbiosis and Ecological Dynamics in the Arctic.Evolutionary anthropology · 2025Review
- Genetic and Anatomical Determinants of Olfaction in Dogs and Wild Canids.Molecular biology and evolution · 2025Article
- Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug.Chemical senses · 2025Article
- Phenotypic and Complete Reference Whole Genome Sequence Analyses of TwoVeterinary sciences · 2025Article
- Adaptation in the Alleyways: Candidate Genes Under Potential Selection in Urban Coyotes.Genome biology and evolution · 2025Article
- Impact of trainability on telomere dynamics of pet dogs (Canis lupus familiaris): An explorative study in aging dogs.PloS one · 2025Article
- A new future for dog breeding.Animal welfare (South Mimms, England) · 2025Review
- Article
- Bringing the Genomic Revolution to Comparative Oncology: Human and Dog Cancers.Annual review of biomedical data science · 2024Review
- Retrospective Study of 222 Dogs Suffering from Food-Responsive Enteropathy-Correlation with Clinical Variables, Diet and Breed.Veterinary sciences · 2024Article
- Millets, dogs, pigs and permanent settlement: productivity transitions in Neolithic northern China.Evolutionary human sciences · 2024Review
- Copy number variant scan in more than four thousand Holstein cows bred in Lombardy, Italy.PloS one · 2024Article
- Human subsistence and signatures of selection on chemosensory genes.Communications biology · 2023Article
- The Australasian dingo archetype: de novo chromosome-length genome assembly, DNA methylome, and cranial morphology.GigaScience · 2023Article
- The Australasian dingo archetype:bioRxiv : the preprint server for biology · 2023Article
- Dingoes, companions in life and death: The significance of archaeological canid burial practices in Australia.PloS one · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shift related to the subsequent development of agriculture. Previous efforts to study this process were based on geographically limited data sets and low-resolution methods, and it is therefore not known to what extent the diet adaptations are universal among dogs and whether there are regional differences associated with alternative human subsistence strategies. Here we use droplet PCR to investigate worldwide AMY2B copy number diversity among indigenous as well as breed dogs and wolves to elucidate how a change in dog diet was associated with the domestication process and subsequent shifts in human subsistence. We find that AMY2B copy numbers are bimodally distributed with high copy numbers (median 2n
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.