Evidence map›Paper›PMID 27406608›Full record

ArticleCirculation. Arrhythmia and electrophysiology2016

Resolving Myocardial Activation With Novel Omnipolar Electrograms.

Stéphane Massé, Karl Magtibay, Nicholas Jackson, John Asta, Marjan Kusha, Boyang Zhang, Ram Balachandran, Milica Radisic, D Curtis Deno, Kumaraswamy Nanthakumar

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Impact of Catheter Configuration on the Mapping of Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Orientation of conduction velocity vectors on cardiac mapping surfaces.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Updates in Ventricular Tachycardia Ablation.Korean circulation journal · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Stéphane MasséFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Karl MagtibayFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Nicholas JacksonFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
John AstaFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Marjan KushaFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Boyang ZhangFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Ram BalachandranFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Milica RadisicFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
D Curtis DenoFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
Kumaraswamy NanthakumarFrom the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith its inherent limitations, determining local activation times has been the basis of cardiac mapping for over a century. Here, we introduce omnipolar electrograms that originate from the natural direction of a travelling wave and from which instantaneous conduction velocity amplitude and direction can be computed at any single location without first determining activation times. We sought to validate omnipole-derived conduction velocities and explore potential application for localization of sources of arrhythmias. METHODS AND

resultsElectrograms from omnipolar mapping were derived and validated using 4 separate models and 2 independent signal acquisition methodologies. We used both electric signals and optical signals collected from monolayer cell preparations, 3-dimensional constructs built with cardiomyocytes derived from human embryonic stem cells, simultaneous optical and electric mapping of rabbit hearts, and in vivo pig electrophysiology studies. Conduction velocities calculated from omnipolar electrograms were compared with wavefront propagation from optical and electric-mapping studies with a traditional local activation time-based method. Bland-Altman analysis revealed that omnipolar measurements on optical data were in agreement with local activation time methods for wavefront direction and velocity within 25 cm/s and 30°, respectively. Similar agreement was also found on electric data. Furthermore, mathematical operations, such as curl and divergence, were applied to omnipole-derived velocity vector fields to locate rotational and focal sources, respectively.

conclusionsElectrode orientation-independent cardiac wavefront trajectory and speed at a single location for each cardiac activation can be determined accurately with omnipolar electrograms. Omnipole-derived vector fields, when combined with mathematical transforms may aid in real-time detection of cardiac activation sources.

Indexed as

Models, CardiovascularAlgorithmsAnimalsAnimals, NewbornArrhythmias, CardiacElectrocardiographyEpicardial MappingHumansMicePluripotent Stem CellsRabbitsReproducibility of ResultsSignal Processing, Computer-AssistedSwineTime Factorscardiac arrhythmiacardiac electrophysiologycatheter ablationconduction velocityomnipole

Identifiers

PMID27406608
PMCPMC4956680
OpenAlexW2460745984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.