ArticleEmerging microbes & infections2016
A fatal yellow fever virus infection in China: description and lessons.
Article in Emerging microbes & infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Technical validation and implementation of a multiplex real-time PCR for differential diagnostic detection of Zika virus, yellow fever virus, dengue virus and chikungunya virus (ZYDC-PCR).BMC infectious diseases · 2026Article
- Yellow Fever, an Arboviral Disease with Public Health Impacts: General Aspects and the Use of the One Health Approach in the Context of This Zoonosis.Infection and drug resistance · 2026Review
- Arthropod-borne encephalitis: an overview for the clinician and emerging considerations.Postgraduate medical journal · 2023Review
- Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology.Pathogens (Basel, Switzerland) · 2023Article
- Risk Factors for Acute Kidney Injury and Death in Patients Infected With the Yellow Fever Virus During the 2018 Outbreak in São Paulo, Brazil.Kidney international reports · 2022Article
- Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Comparison of third-generation sequencing approaches to identify viral pathogens under public health emergency conditions.Virus genes · 2020Article
- Article
- Flavivirus Cross-Reactivity to Dengue Nonstructural Protein 1 Antigen Detection Assays.Diagnostics (Basel, Switzerland) · 2019Article
- Identification ofBiosafety and health · 2019Article
- Review
- Yellow Fever: Factors Associated with Death in a Hospital of Reference in Infectious Diseases, São Paulo, Brazil, 2018.The American journal of tropical medicine and hygiene · 2019Article
- Boosting Global Yellow Fever Vaccine Supply for Epidemic Preparedness: 3 Actions for China and the USA.Virologica Sinica · 2019Article
- Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection.Virologica Sinica · 2019Article
- The distribution of important sero-complexes of flaviviruses in Malaysia.Tropical animal health and production · 2019Review
- Lipase and factor V (but not viral load) are prognostic factors for the evolution of severe yellow fever cases.Memorias do Instituto Oswaldo Cruz · 2019Article
- Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat.Journal of clinical microbiology · 2018Review
- Phylogenomic analysis unravels evolution of yellow fever virus within hosts.PLoS neglected tropical diseases · 2018Article
- Review
- Yellow fever in the diagnostics laboratory.Emerging microbes & infections · 2018Review
Corrections and comments
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Authors and funding
27 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yellow fever (YF) is a viral disease endemic to the tropical regions of Africa and South America. An outbreak of YF has been occurring in Angola, since the beginning of 2016. In March 2016, a 32-year-old Chinese man who returned from Angola was hospitalized and diagnosed with the first case of imported YF in China. Clinical observations, blood viral RNA detection, serological testing and treatments for the patient were performed daily. The virus was isolated in Vero cells, and the complete viral genome was sequenced and analyzed using the next-generation genomic sequencing platform. The patient presented with hemorrhagic fever, jaundice and oliguria at day 3 after onset, which rapidly progressed to multisystem organ failure with extremely elevated liver, pancreatic and myocardial enzymes. The patient died despite the intensive supportive treatments that were performed. A liver biopsy showed severe and multilobular necrosis. Viral RNA was detectable throughout the clinical course of the disease. Whole-genomic sequence analysis revealed that the virus belongs to the Angola71 genotype. Although the virus has been circulating in Angola for 45 years, only 14 amino-acid substitutions and no amino-acid changes were observed in the membrane and envelope proteins compared with the virus collected in 1971. The presence of this imported YF case in China indicated that with the increase in business travel among countries, YF outbreaks in Africa can lead to the international spread of the disease. The production and use of YF vaccines is, therefore, an urgent issue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.