ArticleCognitive, affective & behavioral neuroscience2016
Intolerance of uncertainty and insula activation during uncertain reward.
Article in Cognitive, affective & behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of uncertainty processing: meta-analysis of fMRI studies.Frontiers in neuroscience · 2025Pooled it
- The Effect of Intolerance of Uncertainty on Indecisiveness in Anxiety and Obsessive-Compulsive Disorders.Journal of clinical psychology · 2026Trial
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- Individual differences in intolerance of uncertainty is primarily linked to the structure of inferior frontal regions.Cognitive, affective & behavioral neuroscience · 2025Article
- Beyond reward learning deficits: Exploration-exploitation instability reveals computational heterogeneity in value-based decision making in early psychosis.medRxiv : the preprint server for health sciences · 2025Article
- Impact of Intolerance of Uncertainty on Brain Structural Changes in Panic Disorder.Psychiatry investigation · 2023Article
- Ecstatic or Mystical Experience through Epilepsy.Journal of cognitive neuroscience · 2023Article
- Intolerance of Uncertainty and Cognition in Breast Cancer Survivors: The Mediating Role of Anxiety.Cancers · 2023Article
- Intolerance of uncertainty and functional connectivity of the anterior insula during anticipation of unpredictable reward.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Intolerance of uncertainty heightens negative emotional states and dampens positive emotional states.Frontiers in psychiatry · 2023Article
- Reward-based reinforcement learning is altered among individuals with a history of major depressive disorder and psychomotor retardation symptoms.Journal of psychiatric research · 2022Article
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
- Epilepsy and Ecstatic Experiences: The Role of the Insula.Brain sciences · 2021Review
- Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing.Social cognitive and affective neuroscience · 2021Article
- Mental Capacity, Decision-Making and Emotion Dysregulation in Severe Enduring Anorexia Nervosa.Frontiers in psychiatry · 2021Article
- Functional connectivity of the anterior insula associated with intolerance of uncertainty in youth.Cognitive, affective & behavioral neuroscience · 2020Article
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
- Approach, avoidance, and the detection of conflict in the development of behavioral inhibition.New ideas in psychology · 2019Article
- Ventrolateral prefrontal cortex activation during social exclusion mediates the relation between intolerance of uncertainty and trait aggression.Clinical psychological science : a journal of the Association for Psychological Science · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Individuals with high intolerance of uncertainty (IU) have been shown to exhibit abnormal threat responding, which may be mediated by hyperactive anterior insula (aINS) response to uncertainty. Research has indicated that individuals with high IU also exhibit abnormal positive valence responding, suggesting that IU may impact responding to uncertainty regardless of the valence of the potential outcome. To date, no study has investigated the neural processes associated with IU and response to uncertain positive stimuli, such as rewards. Therefore, this study was designed to examine the association between individual differences in IU and neural activation during uncertain reward using functional magnetic resonance imaging (fMRI). Thirty-seven adults completed a self-report measure of IU and a reward task during fMRI. Consistent with the threat literature, greater IU was associated with increased aINS activation during uncertain reward. This association was more robust for the prospective IU subscale, a dimension characterized by worry about future events. Together with prior studies, these findings provide evidence that IU is related to abnormal threat and reward responding, and that these deficits may be similarly linked to hyperactive aINS response to uncertainty.
Indexed as
Identifiers
27406084What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.